Results 231 to 240 of about 1,423,524 (284)

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

pH-Sensitive Amino Lipid-Driven Pore Formation Enables Endosomal Escape of Lipid Nanoparticles. [PDF]

Nat Commun
Singh AP, Shibata K, Miyazaki Y, Shinoda W.   +3 more
europepmc   +1 more source

Hydrophobic Tail and Linker Diversification of PEG-Lipids Unlocks Precise Muscle Tropism of mRNA-Lipid Nanoparticles. [PDF]

Small
Ou B, Tang X, Qian S, Chen B, Fang S, Su J, Sheng X, Feng J, Yuan Z, Zhang J.   +9 more
europepmc   +1 more source

Overcoming delivery barriers of large all-in-one CRISPR/Cas9 plasmids using lysine-based lipid nanoparticles. [PDF]

Front Genome Ed
Sung W, Li T, Takeoka S.
europepmc   +1 more source

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Stability of Lipid Excipients in Solid Lipid Nanoparticles

Advanced Drug Delivery Reviews, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
exaly   +3 more sources

Solid Lipid Nanoparticles for Parenteral Drug Delivery

Advanced Drug Delivery Reviews, 2004
This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as "solid lipid nanoparticles" (SLN), "nanostructured lipid carriers" (NLC)
Oliver Kayser, R H Müller, R H Müller
exaly   +3 more sources

Lipid Packing in Lipid-Wrapped Nanoparticles

The Journal of Physical Chemistry B, 2018
Equilibrium simulations of lipid-wrapped nanoparticles (LNP) were performed using a hybrid molecular dynamics/Monte Carlo (MD/MC) approach. The radius, R, of a spherical nanoparticle (NP) core was adjusted with MC moves while a surrounding lipid bilayer was treated with MD.
David Stelter, Tom Keyes
openaire   +2 more sources

Lipid Nanoparticles for the Delivery of Biopharmaceuticals

Current Pharmaceutical Biotechnology, 2015
Biopharmaceuticals comprise therapeutic protein-based, nucleic acids and cell-based products. According to their therapeutic success, the clinical use of these products has been growing. Therefore, the development of efficient biopharmaceuticals delivery systems, which overcome their limitations for administration, remains an excellent prospect for ...
Silva, Ana Catarina, Amaral, M.H., Lobo, J.M. Sousa, Lopes, Carla Martins   +3 more
openaire   +3 more sources

LIPID NANOPARTICLES

MIRANDA OSCAR R, ZHAO HAITAO, SUN XIAOFENG   +2 more
  +21 more sources