Results 241 to 250 of about 63,616 (299)
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
Protein Science, Volume 35, Issue 3, March 2026.Abstract NDRG1 is a multifunctional regulatory human protein implicated in crucial cellular processes and acting as a central hub of a cancer‐related interactome. In lung cancer, increased NDRG1 expression is associated with resistance to chemotherapy and is linked to the cellular response to nickel, a known tumor driver in air pollution.
Noemi Carosella +9 more
wiley +1 more source
Small, Volume 22, Issue 16, 17 March 2026.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Small, Volume 22, Issue 16, 17 March 2026.Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi +13 more
wiley +1 more source
Computational Microscopy of Lipid Confined Systems: Challenges and Opportunities
Small Structures, Volume 7, Issue 3, March 2026.This article highlights modular building‐block approaches for constructing confined lipid‐based systems, alongside emerging methods for dynamic 3D data extraction, analysis, and visualization. By surveying current strategies and tools, it outlines how researchers can better harness molecular dynamics simulations, high‐performance computing, and ...
Petra Čechová +7 more
wiley +1 more source
Small Structures, Volume 7, Issue 3, March 2026.Exosomes (small extracellular vesicles) are nanosized vesicles produced naturally by living cells. They can be engineered by various techniques to deliver biologically active molecules to injury sites in atherosclerosis and atherothrombosis. Therefore, an exosome‐based multifunctional nanomedicine for the diagnosis, monitoring, and treatment of these ...
Tuan Huu Nguyen +4 more
wiley +1 more source
Small Structures, Volume 7, Issue 3, March 2026.This graphical abstract summarizes the current advances in dietary exosome‐like nanoparticles (ELNs), highlighting their biogenesis pathways (MVB‐dependent, vacuole‐mediated, and EXPO routes), molecular composition (nucleic acids, lipids, proteins, and bioactive compounds), and major preparation strategies including differential ultracentrifugation ...
Nidesha Randeni +3 more
wiley +1 more source
Molecular Plant Pathology, Volume 27, Issue 3, March 2026.Multi‐control proximity labelling identifies host factors at ER‐organelle interfaces. NbCBP, NbREM1.5 and NbCAS interact with the PlAMV MET domain and restrict viral replication. ABSTRACT Plant positive‐strand RNA viruses establish viral replication complexes (VRCs) by remodelling intracellular membranes, primarily the endoplasmic reticulum (ER) and ...
Yi‐Chen Chang +7 more
wiley +1 more source
Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication
Chemistry – A European Journal, Volume 32, Issue 8, 23 February 2026.This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin +3 more
wiley +1 more source