Results 241 to 250 of about 64,062 (299)

Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology

Biomedical Chromatography, Volume 40, Issue 4, April 2026.
ABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Haifeng Liu, Rongmei Zhao, Hong Xu, Tabusi Manaer, Le Pan, Lu Jin, Amatjan Ayupbek   +6 more
wiley   +1 more source

Human Peripheral Myelin Protein 2 and Charcot–Marie–Tooth Disease or Structural Missense Variants Show Different Binding to Myelin‐Like Lipid Monolayers

ChemBioChem, Volume 27, Issue 8, April 2026.
We compare the membrane affinity of the P2 myelin protein and its Charcot–Marie–Tooth disease variants on a myelin‐like lipid monolayer. Epifluorescence microscopy reveals different two‐dimensional (2D) clustering and pressure‐dependent binding. Single‐point mutations in the P2 β‐barrel and α‐helix affect affinity.
Florian Arndt Schöffmann, Md Abdus Shukur Imran, Christian Schwieger, Øystein Hetland, Vanessa Jerschabek, Arne Raasakka, Petri Kursula, Dariush Hinderberger   +7 more
wiley   +1 more source

Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR. [PDF]

JACS Au
Braun J, Hu Y, Jauch AT, Gronauer TF, Mergner J, Bach NC, Traube FR, Zahler S, Sieber SA.   +8 more
europepmc   +1 more source

Supramolecular Silver Nanoparticle Hydrogels With Controlled Nanoparticle Size and Order: Synthesis Conditions and Possible Mechanism

ChemNanoMat, Volume 12, Issue 4, April 2026.
Nanoparticle (NP)‐gel hybrid systems are multifunctional materials combining the properties of metal NPs with the structural versatility of hydrogels. They find application in advanced technologies, including controlled drug delivery, sensing, flexible electronics, and tissue engineering.
Korin Gasia Ozkaya, Hynd Remita, Isabelle Lampre, Michel Goldmann, Mohamed Selmane, Niki Baccile   +5 more
wiley   +1 more source

Look Who Is Talking: Extracellular Vesicles as Mediators of Intercellular and Interorgan Communication

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Extracellular vesicles (EVs) mediate intercellular and interorgan communication during both physiological and pathological conditions. EVs include exosomes, ectosomes, and apoptotic bodies and contain bioactive molecules. EVs are delivered to proximal cells or can travel in bodily fluids and reach distant organs, where they trigger a response from the ...
Michela Saviana, Giulia Romano, Daniel del Valle‐Morales, Mario Acunzo, Patrick Nana‐Sinkam   +4 more
wiley   +1 more source

Heart–Lung Interactions in Gas Exchange: From Physiology to Pathophysiology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
This review outlines factors compromising the efficiency of alveolar gas exchange. Perturbation in lung fluid balance from capillary and alveolar sources is considered. Safety factors against edema formation are presented. A model is presented to describe gas diffusion limitation considering pulmonary fibrosis, lung resection, heart failure syndromes ...
Giuseppe Miserocchi, Egidio Beretta
wiley   +1 more source

Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer. [PDF]

Cell Mol Life Sci
Gong H, Chen S, Liu S, Hu Q, Li Y, Li Y, Li G, Huang K, Li R, Fang L.   +9 more
europepmc   +1 more source

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Exploration, Volume 6, Issue 2, April 2026.
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, Tae‐Hyung Kim, Jianhuang Xue, Yujun Hou, Ru Zhang   +13 more
wiley   +1 more source

Zhenyuan Solid Drink Ameliorates Inflammation and Oxidative Stress in Isoproterenol‐Induced Ischemic Myocardial Infarction via TLR4/NF‐κB Pathway and PI3K/AKT1/NRF2 Pathway in Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
ZYSD exerts curative and preventive cardioprotection against isoproterenol‐induced myocardial infarction through synergistic interaction with probiotics, exerting antioxidant and anti‐inflammatory effects. ABSTRACT Zhenyuan Solid Drink (ZYSD) is a formulation consisting of 6 medicinal herbs that can be used as both food and medicinal materials in China.
Jiawen Huang, Tian Yu, Guoyi Li, Kechao Nie, Donghua Liu, Cong Meng, Xiaoling Shen, Linchun Fu, Liang Long, Zhuotao Fu, Zhitong Deng, Yingjie Hu   +11 more
wiley   +1 more source

The Role of Gut Microbiome in Obesity and Weight Management: A Review of Current Evidence and Future Directions

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The gut microbiome is critical in controlling host metabolism and body weight. Gut microbial composition and functionality are regulated by external factors such as diet, exercise, medications, and surgical procedures. The microbiome, in turn, affects energy balance, fat storage, and metabolic processes, leading to the development of obesity and weight
Ayesha Rehman, Noman Ali, Muhammad Rizwan Tariq, Shinawar Waseem Ali, Azeem Mushtaq, Waseem Safdar, Abdikhaliq Mursal Yusuf   +6 more
wiley   +1 more source