Results 121 to 130 of about 75,080 (297)

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes.

, 2013
International audience: Previously, we demonstrated that eicosapentaenoic acid enhanced ethanol-induced oxidative stress and cell death in primary rat hepatocytes via an increase in membrane fluidity and lipid raft clustering.
Aliche-Djoudi, Fatiha, Catheline, Daniel,, Chevanne, Martine, Collin, Aurore, Dimanche-Boitrel, Marie-Thérèse, Lagadic-Gossmann, Dominique, Le Hégarat, Ludovic, Legrand, Philippe,, Podechard, Normand, Poul, Martine, Provost, Emilie, Sergent, Odile   +11 more
core   +2 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Characterization of lipid rafts in human platelets using nuclear magnetic resonance: A pilot study

Biochemistry and Biophysics Reports, 2017
Lipid microdomains (‘lipid rafts’) are plasma membrane subregions, enriched in cholesterol and glycosphingolipids, which participate dynamically in cell signaling and molecular trafficking operations.
Joshua F. Ceñido, Boris Itin, Ruth E. Stark, Yung-yu Huang, Maria A. Oquendo, J. John Mann, M. Elizabeth Sublette   +6 more
doaj   +1 more source

Melting transitions in biomembranes

, 2019
We investigated melting transitions in biological membranes in their native state that include their membrane proteins. These membranes originated from \textit{E. coli}, \textit{B.
Heimburg, Thomas, Konrad, Manfred, Madsen, Soren B., Music, Tea, Pollakowski, Denis, Tounsi, Fatma   +5 more
core   +1 more source

Polyvinylidene Fluoride: A Growing Specialty Polymer with Many Facets

Chinese Journal of Chemistry, EarlyView.
Comprehensive Summary Polyvinylidene fluoride (PVDF), the second largest produced fluoropolymer, exhibits outstanding chemical, physical, electroactive and electrochemical properties and is involved in many High‐Tech applications. This review reports recent novelties in synthesis, characterization, processes and applications. Recent preparation studies
Bruno Améduri
wiley   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches. [PDF]

Med Res Rev
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Mavridi D, Katavati T, Kourounakis AP.
europepmc   +2 more sources

Domain formation in membranes with quenched protein obstacles: Lateral heterogeneity and the connection to universality classes

, 2010
We show that lateral fluidity in membranes containing quenched protein obstacles belongs to the universality class of the two-dimensional random-field Ising model.
Fischer, T., Vink, R. L. C.
core   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source