Results 171 to 180 of about 38,146 (252)

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source

Ehg1/May24 stabilizes yeast amino acid permease by facilitating its localization to lipid rafts under high hydrostatic pressure. [PDF]

Mol Biol Cell
Kato Y, Mochizuki T, Mioka T, Kishimoto T, Abe F.   +4 more
europepmc   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts. [PDF]

J Virol
Bolland W, Marechal I, Petiot C, Porrot F, Guivel-Benhassine F, Brelot A, Casartelli N, Schwartz O, Buchrieser J.   +8 more
europepmc   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts. [PDF]

Life Metab
Zhao YY, Li YF, Hao JW, Zhao N, Men XT, Bai XY, Tai R, Ye HB, Du XR, Guo HL, Wang J, Qian HJ, Zhao TJ.   +12 more
europepmc   +1 more source

Molecularly imprinted polymers based electrochemical sensors for biomarker detection in biofluids

InfoScience, Volume 3, Issue 3, September 2026.
This review systematically summarizes the evolution of molecularly imprinted polymer electrochemical sensors from bulk structures to advanced nano‐imprinted architectures. It decouples the complex matrix effects of clinical biofluids and evaluates interfacial engineering strategies for anti‐biofouling.
Tianrui Zhu, Guobao Yao, Haoming Jiang, Yuan Gao, Yinchao Zhao, Hao Shen, Dequn Wu, Qifeng Lu   +7 more
wiley   +1 more source

Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease. [PDF]

Annu Rev Biophys
Pantelopulos GA, Abraham CB, Straub JE.
europepmc   +1 more source