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Lipid Rafts in Neurodegeneration and Neuroprotection
Molecular Neurobiology, 2013The collective properties of the lipids that form biological membranes give rise to a very high level of lateral organization within the membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into specific lipid rafts, which function as dynamic platforms for signal transduction, protein processing, and ...
S. Sonnino +5 more
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Lipid Rafts and Redox Signaling
Antioxidants & Redox Signaling, 2007In addition to the amplifying action of enzymes in the cell-signaling cascade, another important mechanism has been shown to amplify the signals massively when ligands bind to their receptors, which is characterized by clustering of membrane lipid microdomains or lipid rafts and formation of various signaling platforms.
Pin-Lan, Li, Erich, Gulbins
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Lipid rafts and insulin signaling
American Journal of Physiology-Endocrinology and Metabolism, 2002Lipid rafts are domains within the plasma membrane that are enriched in cholesterol and lipids with saturated acyl chains. Specific proteins, including many signaling proteins, segregate into lipid rafts, and this process is important for certain signal transduction events in a variety of cell types.
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Bacterial subversion of lipid rafts
Current Opinion in Microbiology, 2004Bacteria rely on numerous basic cellular functions of their target cells to reach successful infection. The recent discovery that the plasma membrane contains specialized microdomains, called lipid rafts, with many specific functions but in particular with the ability to concentrate signaling molecules, has therefore attracted the attention of cellular
Lafont F, Abrami L, van der Goot FG
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EP24.15 is associated with lipid rafts
Journal of Neuroscience Research, 2003AbstractMetalloendopeptidase EC 3.4.24.15 (EP24.15, thimet oligopeptidase) is a neuropeptide‐metabolizing peptidase expressed throughout the body, but primarily in the brain, gonads, and pituitary. For EP24.15 to have its greatest effect upon peptides in the periphery, it must be targeted and released into the extracellular space. Western blot analysis
Nathaniel A, Jeske +2 more
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Bacterial lipid rafts discovered
Nature Reviews Microbiology, 2010The identification and characterization of bacterial lipid rafts and their role in the signalling pathways that regulate biofilm formation inBacillus subtilis.
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Microdomains Associated to Lipid Rafts
2016Store Operated Ca(2+) Entry (SOCE), the main Ca(2+) influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions ...
Jonathan, Pacheco +2 more
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Direct Evidence of Lipid Rafts by in situ Atomic Force Microscopy
Small, 2012Mingjun Cai, Weidong Zhao, Xin Shang
exaly