Results 201 to 210 of about 75,466 (278)

Gangliosides and cholesterol, two major components of the membrane lipid rafts, as new regulatory partners for stress granules assembly. [PDF]

Cell Stress Chaperones
Aulas A, Di Scala C.
europepmc   +1 more source

Excitatory neurons and astrocytes‐specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single‐cell spatial transcriptomics

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang, Qihang Zou, Yingying Liu, Yinchao Li, Yubao Fang, Tiancai Huang, Jiabin Yu, Lisen Sui, Dezhi Cao, Liemin Zhou   +9 more
wiley   +1 more source

Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques? [PDF]

Membranes (Basel)
Anselmo S, Bonaccorso E, Gangemi C, Sancataldo G, Conti Nibali V, D'Angelo G.   +5 more
europepmc   +1 more source

Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei [PDF]

, 2008
Almeida, Igor C., Engman, David M., Fridberg, Alina, Nakayasu, Ernesto S., Olson, Cheryl L., Tyler, Kevin M.   +5 more
core   +1 more source

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

Lipidome Analysis of Cancer Cells and Their Extracellular Vesicles Reveals Cancer‐Type‐Specific Lipid Signatures and Enables the Design of EV‐Mimetic Liposomes

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Lipid metabolism reprogramming is a hallmark of cancer, yet the global lipidome of cancer cells and their extracellular vesicles (EVs) remains poorly understood. Using mass spectrometry, we analyzed the lipid profiles of a panel of human cancer and non‐cancer cell lines along with their secreted EVs.
Noélie Douanne, Yousra Benslimane, Rubén R. López, Prisca Bustamante, Thupten Tsering, Yunxi Chen, Laura Kienzle, Masoud Ghasemi, Lorne Taylor, Yuning Chen, Anaïs Toreja Boutin, David Juncker, Catherine Mounier, Vahé Nerguizian, Julia V. Burnier   +14 more
wiley   +1 more source

Differential Trafficking Phenotypes of NPC1 Mutant Proteins Reveal Distinct Cholesterol Accumulation Profiles

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Niemann‐Pick disease type C (NPC) is a rare autosomal recessive lysosomal storage disorder that affects approximately 1 in 100 000 live births. It is primarily caused by mutations in the NPC1 gene, which disrupts intracellular cholesterol transport and leads to lipid accumulation in late endosomes and lysosomes.
Sanaa Abdelmalek Mahmoud, AhmedElmontaser Mergani, Maren von Köckritz‐Blickwede, Hassan Y. Naim   +3 more
wiley   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts. [PDF]

Life Metab
Zhao YY, Li YF, Hao JW, Zhao N, Men XT, Bai XY, Tai R, Ye HB, Du XR, Guo HL, Wang J, Qian HJ, Zhao TJ.   +12 more
europepmc   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source