Results 191 to 200 of about 38,146 (252)

Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. [PDF]

Sci Adv
Gad AZ, Morris JS, Godret-Miertschin L, Montalvo MJ, Kerr SS, Berger H, Lee JCH, Saadeldin AM, Abu-Arja MH, Xu S, Vasileiou S, Brock RM, Fousek K, Sheha MF, Srinivasan M, Li Y, Saeedi A, R Levental K, Leen AM, Mamonkin M, Carisey A, Varadarajan N, Hegde M, Joseph SK, Levental I, Levental I, Mukherjee M, Ahmed N.   +27 more
europepmc   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer. [PDF]

Cell Death Discov
Duranti C, Iorio J, Manganelli V, Bagni G, Colasurdo R, Lottini T, Martinelli M, Capitani C, Boso G, D'Alessandro FN, Sorice M, Becchetti A, Misasi R, Garofalo T, Arcangeli A.   +14 more
europepmc   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration. [PDF]

Bioact Mater
Chen N, Li Z, Liu H, Jiang A, Zhang L, Yan S, He W, Yang J, Liu T.   +8 more
europepmc   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity. [PDF]

mBio
Sanduja P, Schmieder SS, Baddal B, Tian S, Velarde JJ, Lencer WI, Dong M, Wessels MR.   +7 more
europepmc   +1 more source

A Generalization of the Ternary Binding Model to Membrane‐Confined Systems With Finite Copy Number

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT The standard Douglass ternary binding model (TBM) for three‐body equilibria assumes a well‐mixed, three‐dimensional solution. When applied to bispecific T‐cell engagers (BiTEs), however, the productive trimeric complex forms not in bulk solution but within a nanoscale membrane synapse with finite receptor copy numbers.
Hamid Bellout, Angela Li, Dean Bottino, Konstantin Piatkov   +3 more
wiley   +1 more source

Advancements and Challenges in Second‐ and Third‐Generation Biofuels: A Comparative Analysis of Lignocellulosic and Algal Feedstocks

Safety Science and Technology, Volume 1, Issue 3, September 2026.
ABSTRACT Advanced biofuels derived from nonfood biomass are increasingly recognized as strategic components of low‐carbon energy systems, particularly for sectors where direct electrification remains difficult. Second‐generation biofuels from lignocellulosic residues and third‐generation biofuels from algal and aquatic biomass offer complementary ...
Majid Saidi, Amirreza Ahmadbozorgi
wiley   +1 more source

Cancer-associated VEGFR2^R1032Q sustains receptor activation also by promoting ligand-independent hetero-dimerization with co-expressed wild-type VEGFR2 and translocation into lipid rafts. [PDF]

Neoplasia
Ravelli C, Corsini M, Bresciani R, Rizzo AM, Zammataro L, Corsetto PA, Grillo E, Mitola S.   +7 more
europepmc   +1 more source