Results 221 to 230 of about 75,466 (278)

Molecular Engineering of the Helminth TGF‐β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF‐β Signaling in Fibroblasts

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham, Claire Ciancia, Tiffany Campion, Maarten van Dinther, Nadia Davis, Anja Duffy, Anna L. L. Heawood, Luke Power, Anna Sanders, Shashi P. Singh, Danielle J. Smyth, Elizabeth Thompson, Ruby White, Andrew P. Hinck, Peter ten Dijke, Rick M. Maizels   +15 more
wiley   +1 more source

Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. [PDF]

Sci Adv
Gad AZ, Morris JS, Godret-Miertschin L, Montalvo MJ, Kerr SS, Berger H, Lee JCH, Saadeldin AM, Abu-Arja MH, Xu S, Vasileiou S, Brock RM, Fousek K, Sheha MF, Srinivasan M, Li Y, Saeedi A, R Levental K, Leen AM, Mamonkin M, Carisey A, Varadarajan N, Hegde M, Joseph SK, Levental I, Levental I, Mukherjee M, Ahmed N.   +27 more
europepmc   +1 more source

Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer. [PDF]

Cell Death Discov
Duranti C, Iorio J, Manganelli V, Bagni G, Colasurdo R, Lottini T, Martinelli M, Capitani C, Boso G, D'Alessandro FN, Sorice M, Becchetti A, Misasi R, Garofalo T, Arcangeli A.   +14 more
europepmc   +1 more source

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts. [PDF]

Elife
Chiu PL, Orjuela JD, de Groot BL, Aponte Santamaría C, Walz T.   +4 more
europepmc   +1 more source

Cancer-associated VEGFR2^R1032Q sustains receptor activation also by promoting ligand-independent hetero-dimerization with co-expressed wild-type VEGFR2 and translocation into lipid rafts. [PDF]

Neoplasia
Ravelli C, Corsini M, Bresciani R, Rizzo AM, Zammataro L, Corsetto PA, Grillo E, Mitola S.   +7 more
europepmc   +1 more source

SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity. [PDF]

mBio
Sanduja P, Schmieder SS, Baddal B, Tian S, Velarde JJ, Lencer WI, Dong M, Wessels MR.   +7 more
europepmc   +1 more source

GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts. [PDF]

Am J Cancer Res
Guo L, He Y, Xin H.
europepmc   +1 more source

Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts. [PDF]

Cell Mol Life Sci
Goldmann O, Lang JC, Rohde M, May T, Molinari G, Medina E.   +5 more
europepmc   +1 more source

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor-ligand binding. [PDF]

Biomech Model Mechanobiol
Bernard C, Carotenuto AR, Pugno NM, Fraldi M, Deseri L.   +4 more
europepmc   +1 more source

Cinobufagin disrupts the stability of lipid rafts by inhibiting the expression of caveolin-1 to promote non-small cell lung cancer cell apoptosis. [PDF]

Arch Med Sci
Xu Z, Li J, Fang S, Lian M, Zhang C, Lu J, Sheng K.   +6 more
europepmc   +1 more source