Results 241 to 250 of about 75,466 (278)
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Lipid rafts in lymphocyte activation
Microbes and Infection, 2004The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation.
PIZZO, PAOLA, VIOLA A.
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Lipid Rafts and Redox Signaling
Antioxidants & Redox Signaling, 2007In addition to the amplifying action of enzymes in the cell-signaling cascade, another important mechanism has been shown to amplify the signals massively when ligands bind to their receptors, which is characterized by clustering of membrane lipid microdomains or lipid rafts and formation of various signaling platforms.
Pin-Lan, Li, Erich, Gulbins
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Bacterial subversion of lipid rafts
Current Opinion in Microbiology, 2004Bacteria rely on numerous basic cellular functions of their target cells to reach successful infection. The recent discovery that the plasma membrane contains specialized microdomains, called lipid rafts, with many specific functions but in particular with the ability to concentrate signaling molecules, has therefore attracted the attention of cellular
Frank, Lafont +2 more
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Lipid Rafts: Feeling is Believing
Physiology, 2004In the late 1990s, accumulated evidence led to the proposal that biological membranes are composed of microdomains of different lipids, which form functional “rafts.” Recent work using atomic force microscopy has given us new insights into the factors influencing the formation and behavior of these physiological microenvironments
Robert M, Henderson +3 more
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Trends in Microbiology, 2005
The intestinal epithelium functions as a physical barrier separating luminal microorganisms from the underlying immune system. There is compelling evidence that several intestinal diseases are associated with the translocation of commensal bacteria across the epithelial barrier.
Erin C, Boyle, B Brett, Finlay
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The intestinal epithelium functions as a physical barrier separating luminal microorganisms from the underlying immune system. There is compelling evidence that several intestinal diseases are associated with the translocation of commensal bacteria across the epithelial barrier.
Erin C, Boyle, B Brett, Finlay
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Microdomains Associated to Lipid Rafts
2016Store Operated Ca(2+) Entry (SOCE), the main Ca(2+) influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions ...
Jonathan, Pacheco +2 more
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Lipid rafts and insulin signaling
American Journal of Physiology-Endocrinology and Metabolism, 2002Lipid rafts are domains within the plasma membrane that are enriched in cholesterol and lipids with saturated acyl chains. Specific proteins, including many signaling proteins, segregate into lipid rafts, and this process is important for certain signal transduction events in a variety of cell types.
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