Results 31 to 40 of about 38,146 (252)
Frontiers in Physiology, 2012 Alterations in the lipid composition of lipid rafts have been demonstrated both in human brain and transgenic mouse models, and it has been postulated that aberrant lipid composition in lipid rafts is partly responsible for neuronal degeneration.
Mario L Diaz +2 more
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SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytess⃞
Journal of Lipid Research, 2007 Although reverse cholesterol transport from peripheral cell types is mediated through plasma membrane microdomains termed lipid rafts, almost nothing is known regarding the existence, protein/lipid composition, or structure of these putative domains in ...
Barbara P. Atshaves +7 more
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Lipid rafts and Alzheimer’s disease: protein-lipid interactions and perturbation of signalling
Frontiers in Physiology, 2012 Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in cholesterol and sphingolipids. They represent a platform for protein-lipid and protein-protein interactions and for cellular signalling events.
David A. Hicks +3 more
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Lipid rafts and membrane traffic [PDF]
FEBS Letters, 2007 Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. We will review their potential involvement in different
Hanzal-Bayer, M. F., Hancock, J. F.
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A simplified method for the preparation of detergent-free lipid rafts
Journal of Lipid Research, 2005 Lipid rafts are small plasma membrane domains that contain high levels of cholesterol and sphingolipids. Traditional methods for the biochemical isolation of lipid rafts involve the extraction of cells with nonionic detergents followed by the separation ...
Jennifer L. Macdonald, Linda J. Pike
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Single virus tracking of Ebola virus entry through lipid rafts in living host cells
Biosafety and Health, 2020 Ebola virus (EBOV) is one of the most pathogenic viruses in humans which can cause a lethal hemorrhagic fever. Understanding the cellular entry mechanisms of EBOV can promote the development of new therapeutic strategies to control virus replication and ...
Cong Jin +9 more
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Journal of Lipid Research, 2009 The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane.
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Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity
Virulence, 2023 Clostridium innocuum is an emerging spore-forming anaerobe that is often observed in Clostridioides difficile-associated inflammatory bowel disease (IBD) exacerbations. Unlike C. difficile, C. innocuum neither produces toxins nor possesses toxin-encoding
Hui-Yu Wu +10 more
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Cholesterol, lipid rafts, and disease [PDF]
Journal of Clinical Investigation, 2002 Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in eukaryotic cells.
Simons, K., Ehehalt, R.
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source