Results 181 to 190 of about 6,052,075 (348)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

open access: yesAdvanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer   +10 more
wiley   +1 more source

Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism. [PDF]

open access: yesMol Metab
Shao LJ   +12 more
europepmc   +1 more source

Epidermal Growth Factor Modulates Palmitic Acid-Induced Inflammatory and Lipid Signaling Pathways in SZ95 Sebocytes. [PDF]

open access: yesFront Immunol, 2021
Törőcsik D   +8 more
europepmc   +1 more source

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

open access: yesAdvanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong   +15 more
wiley   +1 more source

Proliferating or Differentiating Stimuli Act on Different Lipid-dependent Signaling Pathways in Nuclei of Human Leukemia Cells [PDF]

open access: green, 2002
Luca M. Neri   +6 more
openalex   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

open access: yesAdvanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh   +3 more
wiley   +1 more source

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity [PDF]

open access: bronze, 2002
Marc Prentki   +3 more
openalex   +1 more source

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