Results 11 to 20 of about 564,255 (265)

Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

Frontiers in Oncology, 2022
Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine
Xiangwan Miao, Xiangwan Miao, Xiangwan Miao, Beilei Wang, Beilei Wang, Beilei Wang, Kaili Chen, Kaili Chen, Kaili Chen, Rui Ding, Rui Ding, Rui Ding, Jichang Wu, Jichang Wu, Jichang Wu, Yi Pan, Yi Pan, Yi Pan, Peilin Ji, Peilin Ji, Peilin Ji, Bin Ye, Bin Ye, Bin Ye, Mingliang Xiang, Mingliang Xiang, Mingliang Xiang   +26 more
doaj   +1 more source

New Driver for Lipid Synthesis [PDF]

Cell, 2011
Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity.
Houten, Sander M., Argmann, Carmen A.
openaire   +2 more sources

CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis

Frontiers in Cell and Developmental Biology, 2020
Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles in cells.
Nicholas J. Blunsom, Shamshad Cockcroft
doaj   +1 more source

Shelf-life of Moroccan prickly pear (Opuntia ficus-indica) and argan (Argania spinosa) oils: a comparative study

Grasas y Aceites, 2021
Cactus seed oil is gaining considerable popularity in the cosmetic industry. To estimate cactus seed oil’ industrial as well as domestic ease of use, we investigated the oxidative stability of Moroccan cactus seed oil under accelerated aging conditions ...
S. Gharby, D. Guillaume, I. Nounah, H. Harhar, A. Hajib, B. Matthäus, Z. Charrouf   +6 more
doaj   +1 more source

Activity Evaluation of Alcohol Extract of Ginseng-Clove in Inhibiting Lipid Synthesis of Mortierella alpina

Shipin gongye ke-ji, 2022
The inhibitory of lipid synthesis by the alcohol extract of ginseng-clove was explored and its mechanism was preliminarily studied. A lipid screening model of Mortierella alpina (MA) which is rich in fatty acids was established, and 2,3,5 ...
Weifeng NI, Daqing ZHAO, Yiyu NI, Zhulin BAI, Siming WANG   +4 more
doaj   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]

Journal of Lipid Research, 2013
Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance.
Laura V. Danai, Adilson Guilherme, Kalyani V. Guntur, Juerg Straubhaar, Sarah M. Nicoloro, Michael P. Czech   +5 more
doaj   +1 more source

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

Journal of Lipid Research, 2014
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and UCP1-independent processes.
Emilio P. Mottillo, Priya Balasubramanian, Yun-Hee Lee, Changren Weng, Erin E. Kershaw, James G. Granneman   +5 more
doaj   +1 more source

Synthetic biology is essential to unlock commercial biofuel production through hyper lipid-producing microalgae: a review

Applied Phycology, 2021
The multiple drivers of increasing global energy demand, diminishing fossil fuel reserves and the urgent need to mitigate greenhouse gas emissions from non-renewable energy sources have led to a growing international interest in supplementary energy, and
Alberto Rock, Lucie Novoveská, David Green   +2 more
doaj   +1 more source

Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs

Frontiers in Immunology, 2019
CD137 ligand-induced dendritic cells (CD137L-DCs) are a new type of dendritic cells (DCs) that induce strong cytotoxic T cell responses. Investigating the metabolic activity as a potential contributing factor for their potency, we find a significantly ...
Qun Zeng, Qun Zeng, Karthik Mallilankaraman, Herbert Schwarz, Herbert Schwarz   +4 more
doaj   +1 more source