Results 51 to 60 of about 30,990 (296)

Etude des lipides foliaires d'un palmier à huile, Elaeis melanococca x Elaeis guineensis [PDF]

, 1983
Un temps relativement long sépare la jeune plantule de l'arbre en production chez le palmier à huile. Il serait par suite intéressant de définir une relation mathématique entre la composition en acides gras d'une ou plusieurs espèces moléculaires des ...
Biang N'Zie, E., Frater, C., Graille, Jean, Kouamé, Brou, Pina, Michel   +4 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Aerobic Exercise Training Selectively Changes Oxysterol Levels and Metabolism Reducing Cholesterol Accumulation in the Aorta of Dyslipidemic Mice

Frontiers in Physiology, 2017
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the development of atherosclerosis.
Guilherme Silva Ferreira, Paula R. Pinto, Rodrigo T. Iborra, Vanessa Del Bianco, Monique Fátima Mello Santana, Edna Regina Nakandakare, Valéria S. Nunes, Carlos E. Negrão, Sergio Catanozi, Marisa Passarelli   +9 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Paramètres influençant la structure et la fonction du globule rouge chez le cheval [PDF]

, 2007
The erythrocyte, as an oxygen carrier, is submitted to areas where oxidative stress is important. The maintenance of the structure and fluidity of its membrane is essential to its function.
Coudert, Jean, Fellmann, Nicole, Kirschvink, Nathalie, Lekeux, Pierre, Portier, Karine   +4 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Dégermage du maïs au Burkina. Introduction d'un matériel de dégermage du maïs au sein d'une entreprise de tranformation. Expérimentation et adaptation. Approche technico économique : rapport final [PDF]

, 2001
Dans les travaux que mène le Cirad depuis de nombreuses années sur la mise au point d'équipements de transformation, une action sur l'opération de dégermage du mais a été initiée.
Cruz, Jean-François, Dabat, Marie-Hélène, Rivier, Michel   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

La lipidose hépatique chez le cochon d’inde (cavia porcellus) [PDF]

, 2017
Le cochon d’Inde est de plus en plus rencontré dans les salles de consultation du vétérinaire. La lipidose hépatique est un désordre au niveau du stockage des lipides.
Bodin, Pauline
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source