The LUX Score: A Metric for Lipidome Homology. [PDF]
PLoS Computational Biology, 2015 A lipidome is the set of lipids in a given organism, cell or cell compartment and this set reflects the organism's synthetic pathways and interactions with its environment.
Chakravarthy Marella +2 more
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Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study. [PDF]
Sci RepThe plasma lipidome and immune cells are instrumental in shaping the health profile of an organism, and their influence on diseases is profound. However, the intricate interactions between cholangiocarcinoma (CCA) and these physiological components have ...
Yin H, Yang K, Lou Y, Zhao Y.
europepmc +2 more sources
Circulatory lipid signature in response to short-term testosterone gel treatment of healthy young females. [PDF]
Sci RepThe impact of testosterone administration on the circulating lipidome in females remains unexplored, despite its relevance to understanding metabolic disorders like polycystic ovary syndrome (PCOS).
Salamin O +10 more
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Immune Cells as Mediators of Lipidome Influence on Osteoporosis: Evidence from a Mediation Analysis. [PDF]
Diagnostics (Basel)Background: Although clinical studies have indicated a possible association between dyslipidemia and osteoporosis, the underlying genetic basis and mechanistic pathways remain insufficiently defined.
Xiao J +5 more
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White matter lipidome alterations in the schizophrenia brain. [PDF]
Schizophrenia (Heidelb)Numerous brain imaging studies have reported white matter alterations in schizophrenia, but the lipidome analysis of the corresponding tissue remains incomplete.
Senko D +11 more
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Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction. [PDF]
J Lipid ResPresent study explores the role of liver lipidome in driving T2D-associated metabolic changes. Elevated liver triacylglycerols, reduced PUFAs, and 86 differentially abundant lipid species were identified in diabetes-prone mice.
Sehgal R +8 more
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Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods
Scientific Reports, 2023 Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and ...
Miikael Lehtimäki +10 more
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Nature Communications, 2023 Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual-polarity ionization mass spectrometry imaging (MSI) to enable high ...
Hua Zhang +10 more
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Scientific Reports, 2022 This study aimed to determine the lipidome of water buffalo milk with intramammary infection (IMI) by non-aureus staphylococci (NAS), also defined as coagulase-negative staphylococci, using an untargeted lipidomic approach.
Fabrizio Ceciliani +14 more
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Transient Complexity of E. coli Lipidome Is Explained by Fatty Acyl Synthesis and Cyclopropanation
Metabolites, 2022 In the case of many bacteria, such as Escherichia coli, the composition of lipid molecules, termed the lipidome, temporally adapts to different environmental conditions and thus modifies membrane properties to permit growth and survival.
Nikolay V. Berezhnoy +10 more
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