European Journal of Heart Failure, EarlyView.Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun +6 more
wiley +1 more source
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering
Membranes, 2015 We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering.
Norbert Kučerka +3 more
doaj +1 more source
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]
, 2017 Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin +7 more
core +1 more source
Frontiers in Molecular Biosciences, 2021 Background: Coronary stenosis severity determines ischemic symptoms and adverse outcomes. The metabolomic analysis of human fluids can provide an insight into the pathogenesis of complex disease.
Hui Chen +21 more
doaj +1 more source
Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]
, 2015 The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny +114 more
core +1 more source
Lipid Alterations in Early-Stage High-Grade Serous Ovarian Cancer
Frontiers in Molecular Biosciences, 2022 Epithelial ovarian cancer (OC) ranks first in the number of deaths among diseases of the female reproductive organs. Identification of OC at early stages is highly beneficial for the treatment but is highly challenging due to the asymptomatic or low ...
M. V. Iurova +12 more
doaj +1 more source
Frontiers in Marine Science, 2022 The sea urchin Strongylocentrotus intermedius is one of the most economically important echinoids harvested from northeast Pacific Ocean coastal waters.
Heng Wang +7 more
doaj +1 more source
A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature [PDF]
, 2019 The clinical outcome of allogeneic hematopoietic stem cell transplantation (SCT) may be influenced by the metabolic status of the recipient following conditioning, which in turn may enable risk stratification with respect to the development of transplant-
Contaifer, Daniel, Jr. +8 more
core +2 more sources
Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this ...
Shu Xiao, ChaoChao Wei
wiley +1 more source
Holistic lipidomics of the human gut phenotype using validated ultra-high-performance liquid chromatography coupled to hybrid orbitrap mass spectrometry [PDF]
, 2017 As lipids are assigned a plethora of biological functions, it is evident that dysregulated lipid metabolism signifies a key element in many pathological conditions. With this rationale, this study presents a validated lipidomics platform to map the fecal
Bos, Simon +6 more
core +3 more sources