Results 91 to 100 of about 36,600 (265)

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Lipidomic analysis of liver, plasma and adipose tissue in obesity and NAFLD

Lipidomic analysis of liver, plasma, visceral adipose tissue and subcutaneous adipose tissue in participants with ...

core   +1 more source

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

Qualitative and quantitative analysis of ceramide species in biological samples in an untargeted lipidomic profiling platform by high resolution LC-MS

, 2011
Qualitative and quantitative analysis of ceramide species in biological samples in an untargeted lipidomic profiling platform by high resolution LC ...
陈世礼, 周丽娜, 许国旺, 李佳, 赵欣捷, 胡春秀   +5 more
core  

Biochemical Characterization of Lipids, Proteins, and Polysaccharides from the Marine Diatom Phaeodactylum tricornutum Cultivated in Pilot-Scale Photobioreactors

Molecules
Phaeodactylum tricornutum was cultivated in a 1000 L photobioreactors using f/2 medium. The resulting algal biomass contained 24.5% lipids, 37.8% protein, 19.4% carbohydrates, and had a gross energy content of 19.8 MJ/kg.
Arjun H. Banskota, Joseph P. M. Hui, Kaitlyn Blatt-Janmaat, Roumiana Stefanova, Alysson Jones, Sean M. Tibbetts, Patrick J. McGinn   +6 more
doaj   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Lipid Alterations in Chronic Nonspecific Low Back Pain in the Chinese Population: A Metabolomic and Lipidomic Study

Bioengineering
Chronic nonspecific low back pain (cNLBP) accounts for approximately 90% of low back pain cases, affecting 65–80% of the population and significantly impacting life quality and productivity.
Wen Tang, Hong-Jiang Wang, Su-Ying Luo, Si-Yun Zhang, Hao Xie, Hua-Qing Chen, Chu-Huai Wang, Zhou Zhang   +7 more
doaj   +1 more source

AI‐Powered 3D Liver Fat Volumetric Map for Clinical‐Grade Steatosis Assessment From Cross‐Modality MRI

Advanced Intelligent Systems, EarlyView.
An automated, AI‐powered system generates a 3D liver fat volumetric map for precise fat fraction quantification from MRI. By overcoming manual analysis constraints, it provides high‐fidelity spatial characterization of steatosis. This graphical abstract highlights a clinically robust framework that enables efficient, anatomically informed assessment ...
Bincan Deng, Yingyun Gong, Xiao Wang, Xinxi Wang, Dingding Chen, Chen Xuan, Qing Xu, Hongwen Zhou, Yuwen Cui, Manuel Doblare   +9 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Correction: Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr ^-/- mice

, 2019
Correction: Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr ...
PLOS ONE Staff, PLOS ONE (2189197)
core   +1 more source