Results 71 to 80 of about 34,809 (298)

Gastroesophageal Reflux Aspiration in the Post Lung Transplant Patient: a Targeted Bile Acid Metabolomic and Lipidomic Approach.

, 2015
Gastroesophageal Reflux Aspiration in the Post Lung Transplant Patient: a Targeted Bile Acid Metabolomic and Lipidomic ...
Kim C, Shah L, Cremens S, Naroji S, Sonett J, Lederer D, Aramini B, Zhou B, Gilbert DP, D'Ovidio F, Raza K, Arcasoy S, Chan R, Robbins H   +13 more
core   +1 more source

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Frontiers in Cellular and Infection Microbiology, 2022
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation ...
Ronald Lucarelli, Norma Gorrochotegui-Escalante, Jessica Taddeo, Bettina Buttaro, Bettina Buttaro, Joris Beld, Vincent Tam   +6 more
doaj   +1 more source

Subventricular zone lipidomic architecture loss in Huntington's disease

, 2018
The human subventricular zone (SVZ) has a defined cytological and neurochemical architecture, with four constituent laminae that act in concert to support its neurogenic activity.
Angus C. Grey, Maurice A. Curtis, Grey, Angus, Faull, Richard, Richard L. M. Faull, Curtis, Maurice, Mandana Hunter, Demarais, Nicholas, Nicholas J. Demarais, Hunter, Mandana   +9 more
core   +1 more source

Lipidomic signature of stroke recurrence after transient ischemic attack

, 2023
While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR).
G. Arque, M. Portero, A. Ois, A. Rodriguez-Campello, M. Jove, R. Pamplona, F. Purroy, J. Sol, G. Mauri-Capdevila, J. Roquer   +9 more
core   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease

Metabolites, 2020
Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic approach needs to be developed to organize important datasets with the help of bioinformatic tools.
Romain Magny, Anne Regazzetti, Karima Kessal, Gregory Genta-Jouve, Christophe Baudouin, Stéphane Mélik-Parsadaniantz, Françoise Brignole-Baudouin, Olivier Laprévote, Nicolas Auzeil   +8 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

An Updated Overview of Existing Cancer Databases and Identified Needs

Biology, 2023
Our search of existing cancer databases aimed to assess the current landscape and identify key needs. We analyzed 71 databases, focusing on genomics, proteomics, lipidomics, and glycomics.
Brittany K. Austin, Ali Firooz, Homayoun Valafar, Anna V. Blenda   +3 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Lipidomic Characterization of Oocytes at Single-Cell Level Using Nanoflow Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry

Molecules, 2023
Mass spectrometry (MS)-based lipidomic has become a powerful tool for studying lipids in biological systems. However, lipidome analysis at the single-cell level remains a challenge.
Pujia Zhu, Guowei Bu, Ruifeng Hu, Xianqin Ruan, Rongrong Fu, Zhourui Zhang, Qiongqiong Wan, Xin Liu, Yiliang Miao, Suming Chen   +9 more
doaj   +1 more source