Results 61 to 70 of about 36,600 (265)

Lipidomic Characterization of Oocytes at Single-Cell Level Using Nanoflow Chromatography-Trapped Ion Mobility Spectrometry-Mass Spectrometry

Molecules, 2023
Mass spectrometry (MS)-based lipidomic has become a powerful tool for studying lipids in biological systems. However, lipidome analysis at the single-cell level remains a challenge.
Pujia Zhu, Guowei Bu, Ruifeng Hu, Xianqin Ruan, Rongrong Fu, Zhourui Zhang, Qiongqiong Wan, Xin Liu, Yiliang Miao, Suming Chen   +9 more
doaj   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

AAmusic/M.mycoides-and-JCVI-Syn3B-lipidomic-data-filtering-and-analysis: M. mycoides and JCVI Syn3B lipidomic data analysis

<p>Custom python code for the lipidomic data analysis. The code has been written to filter and analyze lipidomic datasets, generated by Lipotype from M. mycoides and JCVI Syn3B membranes. The code does not contain any original packages and utilises
AAmusic
core   +1 more source

Erythrocyte membrane lipidomic profile using 14 fatty acids as a representative cluster.

, 2018
Erythrocyte membrane lipidomic profile using 14 fatty acids as a representative cluster.
Anna Sansone (1882819), Tomasz Ochedalski (5748950), Lucyna Alicja Wozniak (5748956), Izabela Burzynska-Pedziwiatr (5748941), Malgorzata Bukowiecka-Matusiak (5748938), Beata Malachowska (5748944), Chryssostomos Chatgilialoglu (458350), Katarzyna Cypryk (5748953), Carla Ferreri (284957), Monika Zurawska-Klis (5748947)   +9 more
core   +1 more source

A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury

Metabolites, 2020
A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and appropriate medical intervention.
Elisabeth Vicente, Zeljko Vujaskovic, Isabel L. Jackson   +2 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Subventricular zone lipidomic architecture loss in Huntington's disease

, 2018
The human subventricular zone (SVZ) has a defined cytological and neurochemical architecture, with four constituent laminae that act in concert to support its neurogenic activity.
Angus C. Grey, Maurice A. Curtis, Richard L. M. Faull, Mandana Hunter, Nicholas J. Demarais, Hunter, Mandana, Grey, Angus C, Curtis, Maurice A, Demarais, Nicholas J, Faull, Richard LM   +9 more
core   +1 more source

Lipid metabolism in asthmatic patients by lipidomic analysis.

, 2020
Lipid metabolism in asthmatic patients by lipidomic analysis.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Zhe, C (via Mendeley Data), Zhe, Cheng
core   +1 more source

Atypical Antipsychotics and the Human Skeletal Muscle Lipidome

Metabolites, 2018
Atypical antipsychotics (AAPs) are a class of medications associated with significant metabolic side effects, including insulin resistance. The aim of this study was to analyze the skeletal muscle lipidome of patients on AAPs, compared to mood ...
Kyle J. Burghardt, Kristen M. Ward, Elani J. Sanders, Bradley H. Howlett, Berhane Seyoum, Zhengping Yi   +5 more
doaj   +1 more source