Results 51 to 60 of about 23,923 (256)

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Frontiers in Cellular and Infection Microbiology, 2022
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation ...
Ronald Lucarelli, Norma Gorrochotegui-Escalante, Jessica Taddeo, Bettina Buttaro, Bettina Buttaro, Joris Beld, Vincent Tam   +6 more
doaj   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Lipidomic Profiling Reveals HSD17B13 Deficiency-Associated Dysregulated Hepatic Phospholipid Metabolism in Aged Mice

Metabolites
Objectives: HSD17B13 (17β-hydroxysteroid dehydrogenase 13), a lipid droplet-associated enzyme, has emerged as a key regulator of hepatic lipid metabolism and a potential therapeutic target for metabolic-associated fatty liver disease (MAFLD).
Cong Zhang, Yingxin Feng, Xiaoyan Zhang, Youfei Guan, Wen Su   +4 more
doaj   +1 more source

Chaperonin CCT controls extracellular vesicle production and cell metabolism through kinesin dynamics

Journal of Extracellular Vesicles, 2023
Cell proteostasis includes gene transcription, protein translation, folding of de novo proteins, post‐translational modifications, secretion, degradation and recycling. By profiling the proteome of extracellular vesicles (EVs) from T cells, we have found
Amelia Rojas‐Gómez, Sara G. Dosil, Francisco J. Chichón, Nieves Fernández‐Gallego, Alessia Ferrarini, Enrique Calvo, Diego Calzada‐Fraile, Silvia Requena, Joaquin Otón, Alvaro Serrano, Rocio Tarifa, Montserrat Arroyo, Andrea Sorrentino, Eva Pereiro, Jesus Vázquez, José M. Valpuesta, Francisco Sánchez‐Madrid, Noa B. Martín‐Cófreces   +17 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles

Cells, 2020
Recent data have found that aging-related hearing loss (ARHL) is associated with the development of Alzheimer’s Disease (AD). However, the nature of the relationship between these two disorders is not clear. There are multiple potential factors that link
Daniel A. Llano, Lina K. Issa, Priya Devanarayan, Viswanath Devanarayan, Alzheimer’s Disease Neuroimaging Initiative (ADNI)   +4 more
doaj   +1 more source

An Updated Overview of Existing Cancer Databases and Identified Needs

Biology, 2023
Our search of existing cancer databases aimed to assess the current landscape and identify key needs. We analyzed 71 databases, focusing on genomics, proteomics, lipidomics, and glycomics.
Brittany K. Austin, Ali Firooz, Homayoun Valafar, Anna V. Blenda   +3 more
doaj   +1 more source

Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics

PLoS ONE, 2012
Mass spectrometry-based shotgun lipidomics has enabled the quantitative and comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces cerevisiae has proven to be a particularly valuable experimental system for studying lipid-related cellular processes.
Klose, C., Surma, M., Gerl, M., Meyenhofer, F., Shevchenko, A., Simons, K.   +5 more
openaire   +5 more sources

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease

Metabolites, 2020
Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic approach needs to be developed to organize important datasets with the help of bioinformatic tools.
Romain Magny, Anne Regazzetti, Karima Kessal, Gregory Genta-Jouve, Christophe Baudouin, Stéphane Mélik-Parsadaniantz, Françoise Brignole-Baudouin, Olivier Laprévote, Nicolas Auzeil   +8 more
doaj   +1 more source