Results 101 to 110 of about 42,427 (286)

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism [PDF]

, 2017
Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets.
Braicu, Elena Ioana, Budczies, Jan, Darb-Esfahani, Silvia, Denkert, Carsten, Dietel, Manfred, Frezza, Christian, Heiskanen, Laura, Hilvo, Mika, Koistinen, Kaisa M., Kuhberg, Marc, Pöhö, Päivi, Schmitt, Wolfgang D., Sehouli, Jalid   +12 more
core   +3 more sources

A Mouse Macrophage Lipidome [PDF]

Journal of Biological Chemistry, 2010
We report the lipidomic response of the murine macrophage RAW cell line to Kdo(2)-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and compactin, a statin inhibitor of cholesterol biosynthesis.
Dennis, Edward A, Deems, Raymond A, Harkewicz, Richard, Quehenberger, Oswald, Brown, H Alex, Milne, Stephen B, Myers, David S, Glass, Christopher K, Hardiman, Gary, Reichart, Donna, Merrill, Alfred H, Sullards, M Cameron, Wang, Elaine, Murphy, Robert C, Raetz, Christian RH, Garrett, Teresa A, Guan, Ziqiang, Ryan, Andrea C, Russell, David W, McDonald, Jeffrey G, Thompson, Bonne M, Shaw, Walter A, Sud, Manish, Zhao, Yihua, Gupta, Shakti, Maurya, Mano R, Fahy, Eoin, Subramaniam, Shankar   +27 more
openaire   +4 more sources

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine [PDF]

, 2016
In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents.
A Acera, A Alonso, A Enríquez-de-Salamanca, A Enríquez-de-Salamanca, A Enríquez-de-Salamanca, A Ghaffariyeh, A Jemal, A Lambiase, A Lebrecht, A Lebrecht, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A Leonardi, A López-Miguel, A López-Miguel, A Peral, A Rentka, A Rentka, A Riemens, A Satici, A Solomon, AM Lemp, AP Smith, B Houser, B Li, B Ujhelyi, Biomarkers Definitions Working Group, BL Kolozsvári, C Aass, C Costagliola, C Galbis-Estrada, C Galbis-Estrada, C Joffre, C Lebrun, C Salvisberg, C Symeonidis, C Tamer, CG Begley, CM Cheung, CM Tanner, CS Paiva De, D Böhm, D Devos, D Huang, D Karamichos, D Pieragostino, D Pieragostino, D Pieragostino, DK Sen, E Csősz, E Nivenius, E Papavasileiou, E Toker, E Uchio, EA Mahmoud, EB Cook, EB Cook, EM Messmer, FH Grus, G Danaei, G Geerling, G Grech, G Martino, GU Kallarackal, GW Ousler, H Lam, H Link, HG Boersma, HJ Kim, HR Taylor, HV Nema, IA Mackie, J Jin, J Shoji, J Shoji, J Soria, J Tauber, J You, J You, JB Roedl, JC Pong, JC Pong, JE Moore, JF Huang, JG Ladas, JM Holopainen, JM Holopainen, JW Jung, K Cai, KC Yoon, KC Yoon, KK Nichols, KR VanDerMeid, KS Na, KS Park, L Cocho, L Tong, L Tong, L Zhou, L Zhou, L Zhou, M Börger, M Calonge, M Mavra, M Mrugacz, M Mrugacz, M Mrugacz, M Sacchetti, M Schicht, M Tesón, M Tishler, M Zandbelt, MA Lemp, MA Mowafy, MB Abelson, MB Goren, ME Stern, MH Jagasia, ML Massingale, N Boehm, N Boehm, N Dong, N Matheis, N Thun Und Hohenstein-Blaul von, N Tomosugi, O Golubnitschaja, O Golubnitschaja, OD Schein, P Aragona, P Argüeso, P Chhadva, P Versura, PG Montan, PK Coyle, PK Coyle, PS Goedegebuure, Q Guo, R Ihnatko, R Sack, R Shetty, R Sorkhabi, R Tailor, S Chotikavanich, S Darougar, S D’Souza, S Gutman, S Hagan, S Hagan, S Rusnak, S Vujosevic, S Yavuz, SA Lim, SC Pflugfelder, SF Hamm-Alvarez, SG Wu, SM Lam, SM Lam, SS Çomoğlu, SV Aluru, SY Lee, T Göncü, T Matsumura, T Nguyen-Khuong, T Peto, T Sakimoto, T Skwor, TH Wakamatsu, V Evans, VA Smith, VV Kapetanakis, W Choi, W Choi, W Liu, X Tan, Y Ogawa, Y Ohashi, YC Tham, YS Rabinowitz, Z Lei, Z Torok, Z Torok   +183 more
core   +2 more sources

Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem, Bali Pulendran, Rino Rappuoli, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Lipidomic analysis of fats and oils – a lot more than just omega-3 [PDF]

, 2014
TKS research is supported in part by the Wellcome Trust, SUSLA, BBSRC and the European Community’s Seventh Framework Programme under grant agreement No.
Smith, Terry K
core   +1 more source

Evaluation of Lipid Quality in Fruit: Utilizing Lipidomic Approaches for Assessing the Impact of Biotic Stress on Pecans (Carya illinoinensis)

Foods
There is a scarcity of data on how the lipid composition of oily seeds changes in response to biotic stress. Yellow peach moth (Conogethes punctiferalis) has caused massive economic losses on the pecan (Carya illinoinensis) industry.
Lingyuan Zhou, Wei Zhang, Qingyang Li, Maokai Cui, Danyu Shen, Jinping Shu, Runhong Mo, Yihua Liu   +7 more
doaj   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Clinical symptom improvement and lipidomic signatures in overweight/obese PCOS treated by lifestyle and acupuncture intervention

Frontiers in Medicine
BackgroundPolycystic ovary syndrome (PCOS) is interrelated with obesity. Lifestyle intervention, mainly focusing on weight loss, has emerged as promising strategies to improve fertility outcomes in women with obesity.
Haolin Zhang, Haolin Zhang, Wenmin Tian, Dong Li, Dong Li, Yang Chen, Yang Ye, Yang Ye, Zejun Huo, Zejun Huo, Li Shi, Ii Fukuzawa, Ii Fukuzawa, Shuhan Yang, Shuhan Yang, Yang Yang, Yang Yang, Hua Zhang, Lin Zeng, Xiyan Xin, Xiyan Xin, Chunyong Wang, Wen Ma, Weiyu Qiu, Zhihui Qi, Heng Dai, Na Li, Haining Wang, Rong Li, Rong Li   +29 more
doaj   +1 more source