Results 171 to 180 of about 41,885 (269)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Specific Lipidomic Shifts in Chronic Lymphocytic Leukemia at Diagnosis. [PDF]

Cancers (Basel)
Wojnicka J, Kiełbus M, Mertowska P, Mertowski S, Grywalska E, Sosnowski P, Wielgosz A, Kozub-Pędrak A, Sosnowska-Pasiarska B, Klatka M, Klatka J, Błażewicz A.   +11 more
europepmc   +1 more source

Risk factors for strangulating lipoma obstruction and lipomata in horses

Equine Veterinary Journal, EarlyView.
Abstract Background Strangulating lipoma obstruction (SLO) is the most common cause of equine small intestinal strangulation and is fatal without surgery. Currently, epidemiological information is primarily limited to signalment‐related risk factors and requires further investigation.
Alex Gillen, Diana Hassel, Sam W. Gonzalez, Victoria Savage, Margaret Mudge, Andrew Wood, Hattie Barnes, Anje Bauck, David Freeman, Katarzyna Dembek, Liara M. Gonzalez, Debra C. Archer   +11 more
wiley   +1 more source

Lipidomic Profiling of Rabbit VX2 Tumors Using Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging. [PDF]

Radiol Imaging Cancer
Khavandi MM, Crouch AC, Stolley DL, Seeley EH, Cressman ENK.   +4 more
europepmc   +1 more source

Microbiome‐Based Clustering Identifies Glycemic Control‐Related Subtypes in Youth With Recent‐Onset Type 1 Diabetes [PDF]

MedComm (2020)
Microbiome‐based clustering investigated possible glycemic control‐related endotypes in youth with recent‐onset T1D, and found a potential role of Bacteroides and skatole production in glycemic control. This study offers novel perspectives on the influence of intestinal microbes and its metabolites in T1D heterogeneity and lays a foundation for future ...
Tan H, Ding Y, Gu Z, Wang X, Wang J, Wei T, Zhang X, Pan L, Shi Y, Chang S, Guo C, Weng J, Zheng X, Yue T.   +13 more
europepmc   +2 more sources

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease. [PDF]

Int J Mol Sci
Stănoiu-Pînzariu O, Wolters TLC, Socaciu C, Silaghi CA, Valea A, Popa-Ilie I, Hazi G, Socaciu AI, Netea-Maier RT, Georgescu CE.   +9 more
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Successful fecal microbiota transplants in post-antibiotic treated recurrent <i>Clostridioides difficile</i> patients induce acylcarnitine and sphingolipid lipidomic shifts. [PDF]

Gut Microbes Rep
Gancz A, Zhang G, McMillan A, Dougherty M, McGill S, Gulati A, Baker E, Theriot C.   +7 more
europepmc   +1 more source