Results 181 to 190 of about 21,627 (236)

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

COVID-19 is Associated with a Lipid Storm that Worsens in Cases of Severe Pneumonia. [PDF]

Microorganisms
Bouabdallah A, Ben-Fradj MK, Hammami MB, Abdelmalek R, Sanhaji H, Klopfenstein T, Feki M.   +6 more
europepmc   +1 more source

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Advanced Science, Volume 13, Issue 7, 3 February 2026.
An AI‐enabled SERS platform integrates automated exosome enrichment with molecular fingerprinting to enable accurate early detection and differential diagnosis of ten common cancers. The system identifies exosomal dATP as a universal Raman biomarker, offering a scalable, noninvasive, and clinically translatable approach for precision oncology ...
Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen, Jihui Hao   +15 more
wiley   +1 more source

Selective neuronal restoration of progranulin does not prevent the frontotemporal dementia like-phenotype of progranulin knockout mice. [PDF]

J Neuroinflammation
Weyer MP, Hahnefeld L, Franck L, Angioni C, Klein M, Geisslinger G, Schäfer MKE, Tegeder I.   +7 more
europepmc   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Causal link between coronary heart disease and lipidomics: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Kang R, Guo D, Zhang J, Wang J.
europepmc   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, Volume 13, Issue 8, 9 February 2026.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

A Novel Rat Model for Human Meibomian Gland Dysfunction and Ocular Rosacea. [PDF]

Invest Ophthalmol Vis Sci
Zhu L, Rodrigues-Braz D, Gélizé E, Crépin M, Peltier C, Lheure C, Morel X, Bourges JL, Berdeaux O, Behar-Cohen F, Zhao M.   +10 more
europepmc   +1 more source