Results 121 to 130 of about 40,787 (289)

Rapid characterization of the fatty acyl composition of complex lipids by collision-induced dissociation time-of-flight mass spectrometry

Journal of Lipid Research, 2007
Profiling of leaf extracts from mutants of Arabidopsis with defects in lipid desaturation demonstrates the utility of collision-induced dissociation time-of-flight mass spectrometry (CID-TOF MS) for screening biological samples for fatty acid ...
Steven Wynn Esch, Pamela Tamura, Alexis A. Sparks, Mary R. Roth, Shivakumar P. Devaiah, Ernst Heinz, Xuemin Wang, Todd D. Williams, Ruth Welti   +8 more
doaj   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Plasma proteomics and lipidomics facilitate elucidation of the link between Alzheimer's disease development and vessel wall fragility

Scientific Reports
Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were utilized for the proteomic and lipidomic characterization of plasma specimens from patients who developed Alzheimer's disease.
Suzumi M. Tokuoka, Fumie Hamano, Ayako Kobayashi, Shungo Adachi, Tomohiro Andou, Tohru Natsume, Yoshiya Oda   +6 more
doaj   +1 more source

Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate

EMBO Reports
The chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea.
Philipp Rieche, Mirthe Hoekzema, Sergiy Gan, Greetje A Berrelkamp-Lahpor, Adanna W Ezissi, Marten Exterkate, Arnold J M Driessen   +6 more
doaj   +1 more source

Application of Lipidomics in the Researches of Food Quality

Shipin gongye ke-ji
Lipidomics, as a metabolomics approach centered on lipids, aims to comprehensively analyze lipids within biological systems. In recent years, mass spectrometry (MS)-based lipidomics analysis techniques have been widely utilized to address qualitative and
Haolei HAN, Guangqin LIAO, Yuxuan WU, Houru LI, Yongzhong QIAN, Jing QIU   +5 more
doaj   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Principles and practice of lipidomics

, 2015
The technical advances in mass spectrometry, particularly the development of (ultra)-high-resolution/mass accuracy measurement capabilities in combination with refinement of soft ionization techniques, have increased the application and success of ...
Bootsma, Albert H., Vaz, Frédéric M., Albert H. Bootsma, Antoine H. C. van Kampen, Bootsma, A.H., Mia Pras‐Raves, van Kampen, A.H.C., Frédéric M. Vaz, Vaz, F.M., Pras-Raves, M., Pras-Raves, Mia, van Kampen, Antoine H. C.   +11 more
core   +1 more source

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Arthritis &Rheumatology, Accepted Article.
Objectives Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski, Kimberly E. Taylor, Emily Flynn, Armita Norouzi, Catherine Chu, Brittany Davidson, Arnab Ghosh, Joanne Nititham, Ravi K. Patel, Annie W. Poon, Gabriela K. Fragiadakis, Alexis J. Combes, Walter L. Eckalbar, Lindsey A. Criswell, Chun Jimmie Ye, Caroline H. Shiboski   +15 more
wiley   +1 more source

Accurate long-read transcript discovery and quantification at single-cell, pseudo-bulk and bulk resolution with Isosceles

Nature Communications
Accurate detection and quantification of mRNA isoforms from nanopore long-read sequencing remains challenged by technical noise, particularly in single cells. To address this, we introduce Isosceles, a computational toolkit that outperforms other methods
Michal Kabza, Alexander Ritter, Ashley Byrne, Kostianna Sereti, Daniel Le, William Stephenson, Timothy Sterne-Weiler   +6 more
doaj   +1 more source

Application of lipidomics in the study of traditional Chinese medicine

Journal of Pharmaceutical Analysis
Lipidomics is an emerging discipline that systematically studies the various types, functions, and metabolic pathways of lipids within living organisms.
Yang Yang, Guangyi Yang, Wenpeng Zhang, Lingyi Xin, Jing Zhu, Hangtian Wang, Baodong Feng, Renyan Liu, Shuya Zhang, Yuanwu Cui, Qinhua Chen, Dean Guo   +11 more
doaj   +1 more source