Results 101 to 110 of about 40,787 (289)
Advanced Science, EarlyView.LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao +13 more
wiley +1 more source
Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates
Angewandte Chemie, EarlyView.An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho +5 more
wiley +2 more sources
Lipidomics in vascular health: current perspectives
, 2015 Genovefa Kolovou,1 Vana Kolovou,1,2 Sophie Mavrogeni1 1Cardiology Department, 2Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece Abstract: Identifying the mechanisms that convert a healthy vascular wall to an ...
Kolovou G, Mavrogeni S, Kolovou V
core
Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress
Advanced Science, EarlyView.Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang +18 more
wiley +1 more source
Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A
Beni-Suef University Journal of Basic and Applied SciencesBackground Despite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug resistance, an increase in overall treatment costs, and unanticipated side effects from pharmaceuticals.
Shilpa S. Shetty +2 more
doaj +1 more source
Analysis and Quantification of the Mitochondrial–ER Lipidome
Bio-ProtocolMitochondria are vital organelles essential for cellular functions, but their lipid composition and response to stressors are not fully understood.
Alexis Diaz-Vegas +2 more
doaj +1 more source
Advancing Semen Evaluation Using Lipidomics
, 2021 Developing a deeper understanding of biological components of sperm is essential to improving cryopreservation techniques and reproductive technologies.
Dinh, Thu T.N. +9 more
core +1 more source
Advanced Science, EarlyView.Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan +7 more
wiley +1 more source