Results 91 to 100 of about 40,787 (289)
Nature CommunicationsThe biology of individual lipid species and their relevance in Alzheimer’s disease (AD) remains incompletely understood. To explore the lipidomic biomarkers associated with cognition function and neuropathological changes in AD, we utilize non-targeted ...
Chih-Yu Chen +10 more
doaj +1 more source
Bioinformatics for Quantitative, Targeted Lipidomics Discovery
, 2020 Lipidomics uses high performance liquid chromatography coupled to tandem mass spectrometry via electrospray ionization to comprehensively identify and quantify all lipid species in a biological system.
Chitpin, Justin Gareth
core +1 more source
Advanced Science, EarlyView.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
Signal Transduction and Targeted Therapy, 2021 Lipidomics profiling workflow. (a) Plasma lipidomics extraction was accomplished by fractionating samples into pools of species with similar physicochemical properties using appropriate combinations of organic solvents, after the addition of an internal ...
Jia-Xi Chen +8 more
doaj +1 more source
Advanced Science, EarlyView.High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld +5 more
wiley +1 more source
, 2022 Lipidomics analysis datasheet of human MIGA2 soluble portion (purified from Expi293 cells and gel filtrated)
Zhouping Hong
core +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Lipidomics as a Tool for Functional Genomics in Sinorhizobium Meliloti
, 2008 This thesis focused on the development of comprehensive, rapid and simple methodologies for the analysis of fatty acids by gas chromatography mass spectrometry (GC/MS) and intact lipids by electrospray ionization tandem mass spectrometry (ESIIMS/MS).
Saborido Basconcillo, Libia
core
Advanced Science, EarlyView.Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley +1 more source