Results 91 to 100 of about 36,737 (293)

Integrated analysis of per- and polyfluoroalkyl substances and plasma lipidomics profiles in multi-ethnic Asian subjects for exposome research

Environmental Health
Background Perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure has been associated with metabolic diseases, however, the underlying molecular pathogenesis remains to be understood.
Kothandaraman Narasimhan, Vaitheeswari, Ellie Choi, Nisha Suyien Chandran, Johan G. Eriksson, Anne K. Bendt, Federico Torta, Sartaj Ahmad Mir   +7 more
doaj   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Principles and practice of lipidomics [PDF]

, 2015
The technical advances in mass spectrometry, particularly the development of (ultra)-high-resolution/mass accuracy measurement capabilities in combination with refinement of soft ionization techniques, have increased the application and success of ...
Bootsma, Albert H., Vaz, Frédéric M., Albert H. Bootsma, Antoine H. C. van Kampen, Bootsma, A.H., Mia Pras‐Raves, van Kampen, A.H.C., Frédéric M. Vaz, Vaz, F.M., Pras-Raves, M., Pras-Raves, Mia, van Kampen, Antoine H. C.   +11 more
core   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Lipidomics in disease biomarker discovery: methods and applications [PDF]

, 2012
Lipidomics in disease biomarker discovery: methods and ...
陈世礼, 许国旺, 赵素敏, 李佳, 赵欣捷, 胡春秀, 路鑫   +6 more
core  

Integrative brain omics approach highlights sn-1 lysophosphatidylethanolamine in Alzheimer’s dementia

Nature Communications
The biology of individual lipid species and their relevance in Alzheimer’s disease (AD) remains incompletely understood. To explore the lipidomic biomarkers associated with cognition function and neuropathological changes in AD, we utilize non-targeted ...
Chih-Yu Chen, Kristal Maner-Smith, Manoj Khadka, Jun Ahn, Xueyun L. Gulbin, Anna A. Ivanova, Eric B. Dammer, Nicholas T. Seyfried, David A. Bennett, Ihab M. Hajjar, Eric A. Ortlund   +10 more
doaj   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Lipidomics Data [PDF]

, 2020
Gao et al 2020. Data from lipidomics analyses included in the study entitled: "Phosphatidylglycerol Composition is Central to Chilling Damage in the Arabidopsis fab1 Mutant.
Browse, John, Gao, Jinpeng
core  

Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients

Signal Transduction and Targeted Therapy, 2021
Lipidomics profiling workflow. (a) Plasma lipidomics extraction was accomplished by fractionating samples into pools of species with similar physicochemical properties using appropriate combinations of organic solvents, after the addition of an internal ...
Jia-Xi Chen, Yu-Shuai Han, Shan-Qiang Zhang, Zhi-Bin Li, Jing Chen, Wen-Jing Yi, Huai Huang, Ting-Ting Jiang, Ji-Cheng Li   +8 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source