Results 81 to 90 of about 36,737 (293)
Advanced Science, EarlyView.Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li +8 more
wiley +1 more source
Frontiers in Oncology, 2020 Bladder cancer (BC) and Renal cell carcinoma(RCC) are the two most frequent genitourinary cancers in China. In this study, a comprehensive liquid chromatography—mass spectrometry (LC-MS) based method, which utilizes both plasma metabolomics and ...
Xiang Liu +12 more
doaj +1 more source
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
An automated software pipeline for shotgun lipidomics using direct-infusion, high-resolution mass spectrometry [PDF]
, 2015 In the last ten years, lipidomics has attracted increasing attention as a research tool in a wide range of disciplines including physiology, lipid biochemistry, clinical biomarker discovery and pathology.
S. Kempa +3 more
core
Lipidomics Solutions for Biomedical Research [PDF]
, 2023 Creative Proteomics provides lipidomics solutions in the biomedical field based on GC-MS and high throughput LC-MS/MS technologies. We are capable of performing both untargeted and targeted lipidomics analyses of various panels based on your specific ...
Dora West
core +1 more source
Advanced Science, EarlyView.Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu +11 more
wiley +1 more source
Lipidomics in Health and Diseases - Beyond the Analysis of Lipids [PDF]
, 2014 published_or_final_versio
Li, M, Wang, Y, Fan, P
core +1 more source
BiomoleculesPhospholipid fatty acid incorporation and remodeling are central processes through which immune cells adapt their membranes during activation. Macrophages are known to integrate oxidized fatty acids into phospholipids, yet the principles governing this ...
Alvaro Garrido +4 more
doaj +1 more source
Biomedicines, 2020 Diabetes and its vascular complications affect an increasing number of people. This disease of epidemic proportion nowadays involves abnormalities of large and small blood vessels, all commencing with alterations of the endothelial cell (EC) functions ...
Laura Toma +2 more
doaj +1 more source
Advanced Science, EarlyView.Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang +6 more
wiley +1 more source