Results 161 to 170 of about 8,324 (204)

Cost-effectiveness of different tuberculosis diagnostic approaches in Nigeria based on decision analytical modelling. [PDF]

BMJ Glob Health
Ibrahim HU, Garba RM, Ahmad JI, Abdulsalam K, Jibril YN, Dankishiya FS, Ibrahim A, Garzali IU, Galadanci AA, Suleiman AK, Olawumi AL, Abdullahi UF, Mahmud FM, Umar AA, Asafu-Adjaye O, Owolabi LF, Musa BM, Aliyu MH.   +17 more
europepmc   +1 more source

Roles of Lipoarabinomannan in the Pathogenesis of Tuberculosis

Microbes and Infection, 1999
Tuberculosis is a worldwide public health threat caused by Mycobacterium tuberculosis. All mycobacteria express a unique cell envelope glycolipid, lipoarabinomannan, which can be released at sites of infection. Lipoarabinomannan is a potential virulence factor which can bind to leukocytes and modulate immune responses.
Matthew J Fenton, M J Fenton
exaly   +3 more sources

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Lipid and Lipoarabinomannan Isolation and Characterization

2021
The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria. As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
Daffé, Mamadou, Lanéelle, Marie-Antoinette, Spina, Lucie, Nigou, Jérôme, Lemassu, Anne   +4 more
openaire   +3 more sources

Molecular Mapping of Lipoarabinomannans on Mycobacteria

Langmuir, 2009
Although the chemical composition of mycobacterial cell walls is well known, the 3D organization of the various constituents is not fully understood. In particular, it is unclear whether the major wall component lipoarabinomannan (LAM) is exposed on the outermost surface or hindered by other constituents such as mycolic acids. To address this pertinent
Verbelen, Claire, Christiaens, Nicolas, Alsteens, David, Dupres, Vincent, Baulard, Alain R, Dufrêne, Yves   +5 more
openaire   +3 more sources

Lipoarabinomannans: from structure to biosynthesis

Biochimie, 2003
Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most effective human pathogens and the molecular basis of its virulence remains poorly understood. Here, we review our current knowledge about the structure and biosynthesis of the mycobacterial cell-wall lipoglycans, lipoarabinomannans (LAM).
Nigou, Jérôme, Gilleron, Martine, Puzo, Germain   +2 more
openaire   +3 more sources

Understanding the Interaction of Lipoarabinomannan With Membrane Mimetic Architectures

Tuberculosis, 2012
Lipoarabinomannan (LAM) is a critical virulence factor in the pathogenesis of Mycobacterium tuberculosis, the causative agent of tuberculosis. LAM is secreted in urine and serum from infected patients and is being studied as a potential diagnostic indicator for the disease.
Gabriel A Montano, Ramakrishnan Parthasarathi, Harshini Mukundan   +2 more
exaly   +3 more sources

Detection of Mycobacterial Lipoarabinomannan in Serum for Diagnosis of Active Tuberculosis

Diagnostic Microbiology and Infectious Disease, 2020
Urinary detection of Mycobacterium tuberculosis lipoarabinomannan (LAM) for tuberculosis (TB) diagnosis is well characterized, but the utility of serum LAM detection remains unclear. We developed an assay for serum LAM detection using single-molecule array (Simoa), purified M.
Nira R Pollock, David Hanlon
exaly   +3 more sources