Results 171 to 180 of about 8,324 (204)

Lipid and Lipoarabinomannan Isolation and Characterization

2015
Mycobacteria are microorganisms that contain a very high content of structurally diverse lipids, some of them being biologically active substances. As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species level.
Marie-Antoinette, Lanéelle, Jérôme, Nigou, Mamadou, Daffé   +2 more
openaire   +2 more sources

Mycobacterial Lipoarabinomannan: An Extraordinary Lipoheteroglycan With Profound Physiological Effects. [PDF]

Glycobiology, 1998
Detailed structural and functional studies over the last decade have led to current recognition of the mycobacterial lipoarabinomannan (LAM) as a phosphatidylinositol anchored lipoglycan with diverse biological activities. Fatty acylation has been demonstrated to be essential for LAM to maintain its functional integrity although the focus has largely ...
Delphi Chatterjee, Kay-Hooi Khoo, K H Khoo   +2 more
exaly   +3 more sources

Diagnosis of Tuberculosis by a Visually Detectable Immunoassay for Lipoarabinomannan

American Journal of Respiratory and Critical Care Medicine, 2000
Abstract Recovery of tubercle bacilli from sputum, tissue, or body fluid is the standard for the diagnosis of tuberculosis (TB) although this process is technically demanding and relatively insensitive. We have developed a simplified, visually detectable, colloidal gold-based serological assay to qualitatively detect IgG directed ...
E D, Chan, R, Reves, J T, Belisle, P J, Brennan, W E, Hahn   +4 more
openaire   +2 more sources

Identification of a Lipoarabinomannan-like Lipoglycan in Gordonia rubropertincta

Systematic and Applied Microbiology, 1999
Lipoarabinomannans are well characterised lipoglycans present in the cell envelopes of mycobacteria and closely related bacteria. To define further the distribution of these lipoglycans we have investigated the mycolic acid-containing bacterium Gordonia rubropertincta and, by analysis of carbohydrate composition and antigenic cross-reactivity ...
C, Flaherty, I C, Sutcliffe
openaire   +2 more sources

Circulating Antibodies to Lipoarabinomannan in Relation to Sputum Microscopy, Clinical Features and Urinary Anti-lipoarabinomannan Detection in Pulmonary Tuberculosis

Scandinavian Journal of Infectious Diseases, 2002
An enzyme-linked immunosorbent assay (ELISA)-based investigation of anti-lipoarabinomannan (LAM) antibody levels in the sera of patients with acid-fast bacilli (AFB)-positive pulmonary tuberculosis (PTB), AFB-negative PTB and non-TB respiratory tract symptoms was conducted.
Tsigeweini Asgedom, Tessema, Gunnar, Bjune, Beston, Hamasur, Stefan, Svenson, Heidi, Syre, Bjarne, Bjorvatn   +5 more
openaire   +2 more sources

Extending lipoarabinomannan detection limitations with plasmonic gratings

2017 IEEE SENSORS, 2017
Tuberculosis (TB) is a growing threat that endangers the lives of more than 9.6 million people each year. The early diagnosis and treatment of this disease are critical to preventing serious infections and death. However, accurately diagnosing adults and children in resource-poor regions has proven very difficult.
Aaron Wood, Syed Barizuddin, Sangho Bok, C. Joseph Mathai, Sheila A. Grant, Keshab Gangopadhyay, Shubhra Gangopadhyay   +6 more
openaire   +2 more sources

Lipoarabinomannan antigen and anti-lipoarabinomannan antibody profile in the serum of patients with mycobacterial infections and their significance in disease process

Serodiagnosis and Immunotherapy in Infectious Disease, 1995
Abstract A sandwich antigen capture assay using a double monoclonal antibody system revealed the presence of lipoarabinomannan (LAM) antigen in about 25% of the serum samples in subjects with pulmonary tuberculosis and tuberculoid leprosy. Lepromatous leprosy sera showed about 40% antigen positivity. Anti-LAM antibodies could be detected in about 90%
S.A Patil, G Ramu, M Patil
openaire   +1 more source

Differential tolerance induction by lipoarabinomannan and lipopolysaccharide in human macrophages

Microbes and Infection, 2000
Various bacterial cell wall components have been shown to induce hyporesponsiveness in macrophages (MAC). Here, mycobacterial glycolipids were employed to determine whether they induce a state of 'tolerance/hyporesponsiveness' in MAC in vitro in order to assess whether mycobacterial components negatively affect the immune response to Mycobacterium ...
Riedel, D., Kaufmann, S.
openaire   +3 more sources

Identification of a lipoarabinomannan-like lipoglycan in Corynebacterium matruchotii

Archives of Oral Biology, 1995
The oral organism Corynebacterium matruchotii was investigated for the presence of lipoteichoic acid, as this common polyanionic macroamphiphilic component of Gram-positive bacteria has been implicated in phenomena related to calcium binding. Phenol-water extraction followed by a small-scale, hydrophobic-interaction chromatography step yielded ...
openaire   +2 more sources

Lipoarabinomannan induced cytotoxic effects in human mononuclear cells

FEMS Immunology & Medical Microbiology, 1998
Mycobacteria produce large quantities of lipoarabinomannan, a cell wall associated glycolipid, which confers virulence in many of the disease causing members of the genus. We studied the lipoarabinomannan induced altered signaling mechanism in human peripheral mononuclear cells.
S, Ghosh, S, Pal, S, Das, S K, Dasgupta, S, Majumdar   +4 more
openaire   +2 more sources