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Requirement of lipocalin 2 for chronic myeloid leukemia
Leukemia & Lymphoma, 2008The Bcr-Abl oncoprotein causes chronic myeloid leukemia by a mechanism involving its activated tyrosine kinase. BCR-ABL+ mouse hematopoietic cells persistently express and secrete lipocalin 2 by a mechanism that requires the tyrosine kinase of the Bcr-Abl oncoprotein.
Ralph, Arlinghaus, Xiaohong, Leng
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Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes
Critical Reviews in Immunology, 2015Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration. Recently, we reported that LCN2 is secreted by brain astrocytes under inflammatory conditions and that it promotes apoptosis ...
Shinrye, Lee +2 more
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Lipocalin 2 as a Membrane-Reorganizing Agent
Science Signaling, 2014A protein that binds to diverse hydrophobic substrates reorganizes the sperm plasma membrane in preparation for fertilization.
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Journal of the American Heart Association, 2017 Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart ...
Antti Kangas +2 more
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Relationships of lipocalin 2 with breast tumorigenesis and metastasis
Journal of Cellular Physiology, 2010AbstractBreast cancer is one of the most common cancers in women worldwide and accounts for one‐sixth of cancer deaths in the United States. Breast cancer consists of a heterogeneous group of tumours classified into five types, in which the HER2/neu positive and the basal type (most are ER and HER2 negative) have the worst clinical prognosis. In recent
Xiaohong, Leng +2 more
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Lipocalin‐2 is increased in amyotrophic lateral sclerosis
Muscle & Nerve, 2020AbstractBackgroundThe exact mechanisms underlying neuroinflammation and how they contribute to amyotrophic lateral sclerosis (ALS) pathogenesis remain unclear. One possibility is the secretion of neurotoxic factors, such as lipocalin‐2 (LCN2), that lead to neuronal death.MethodsLCN2 levels were measured in human postmortem tissue using Western blot ...
Tiziana, Petrozziello +9 more
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Graphene-based immunoassay for human lipocalin-2
Analytical Biochemistry, 2014We have developed a highly sensitive immunoassay using graphene nano platelets (GNPs) for the rapid detection of human lipocalin-2 (LCN2) in plasma, serum, and whole blood. It has the dynamic range, linear range, limit of detection, and analytical sensitivity of 0.6 to 5120, 80 to 2560, 0.7, and 1pg/ml, respectively.
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Evaluation of the serum level of Lipocalin 2 in vitiligo
Archives of Dermatological ResearchVitiligo is considered as depigmenting skin disorder where patches of skin losing their pigment. Lipocalin-2 (LCN2) is one of the Inflammatory adipokines that has a potential role in skin disorders and other inflammatory diseases as well. To measure the concentration level of LCN2 in vitiligo patients compared to healthy controls and to investigate its
Marwa A, Nassar +3 more
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The role of lipocalin-2 in the pathophysiology of hidradenitis suppurativa
Clinics in DermatologyLipocalin-2 (LCN-2) is a multifunctional glycoprotein that is weakly expressed in the skin and serum in healthy individuals, but it is associated with a range of inflammatory, metabolic, and cardiovascular conditions. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and tunnels in skin ...
Josko, Mise +2 more
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