Results 61 to 70 of about 11,446 (217)

A novel lipocalin homologue from the venom gland of Deinagkistrodon acutus similar to mammalian lipocalins

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Lipocalins are involved in a variety of functions including retinol transport, cryptic coloration, olfaction, pheromone transport, prostaglandin synthesis, regulation of the immune response and cell homeostatic mediation.
CB Wei, J Chen
doaj   +1 more source

Focus on Molecules: Tear lipocalin [PDF]

Experimental Eye Research, 2011
1. Structure Tear lipocalin, or von Ebner’s gland protein, tear specific prealbumin, (GenBank Accession Number: BC074925; Ref Seq ID: NM_002297; PDB ID: 3EYC, 1XKI) is a 17.45 kDa member of a superfamily christened lipocalins because lipophiles are enclosed within their cup shaped cavity or calyx.
Ben J, Glasgow, Oktay K, Gasymov
openaire   +2 more sources

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Plant-derived chimeric virus particles for the diagnosis of primary Sjögren syndrome

Frontiers in Plant Science, 2015
Plants are ideal for the production of protein-based nanomaterials because they synthesize and assemble complex multimeric proteins that cannot be expressed efficiently using other platforms.
Elisa eTinazzi, Matilde eMerlin, Caterina eBason, Ruggero eBeri, Roberta eZampieri, Chiara eLico, Elena eBartoloni, Antonio ePuccetti, Claudio eLunardi, Mario ePezzotti, Linda eAvesani   +10 more
doaj   +1 more source

Lipocalin 2 – mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals

Frontiers in Endocrinology, 2023
ContextThe bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway.ObjectiveWe aimed to (i) detect variants in the lipocalin-2 gene (LCN2) which are relevant for body weight regulation and ...
Yiran Zheng, Yiran Zheng, Luisa Sophie Rajcsanyi, Luisa Sophie Rajcsanyi, Manuela Kowalczyk, Johanna Giuranna, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stefan Ehrlich, Stephan Zipfel, Stephan Zipfel, Katrin Giel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Saad Al-Lahham, Johannes Hebebrand, Johannes Hebebrand, Dagmar Fuhrer, Dagmar Fuhrer, Susanne Tan, Denise Zwanziger, Triinu Peters, Triinu Peters, Anke Hinney, Anke Hinney   +29 more
doaj   +1 more source

Role of lipocalin 2 in stroke

Neurobiology of Disease, 2023
Stroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell ...
Ruo-Yu Zhao, Peng-Ju Wei, Xin Sun, Dian-Hui Zhang, Qian-Yan He, Jie Liu, Jun-Lei Chang, Yi Yang, Zhen-Ni Guo   +8 more
openaire   +3 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have Different Patterns in Heart Failure Exacerbation [PDF]

, 2013
Individuals with acute heart failure exacerbation often experience a deterioration in renal function. We sought to determine whether this deterioration is ischemic in nature and detectable by sensitive urine biomarkers neutrophil gelatinase-associated ...
Hsu, Chi-yuan, Meyeon Park, Park, Meyeon, Michael G. Shlipak, Chi-yuan Hsu, Vittinghoff, Eric, Liu, Kathleen D, Eric Vittinghoff, Shlipak, Michael G, Kathleen D. Liu   +9 more
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source