Results 1 to 10 of about 35,193 (158)

Role of lipocalin 2 in stroke

Neurobiology of Disease, 2023
Stroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological ...
Ruo-Yu Zhao, Peng-Ju Wei, Xin Sun, Dian-Hui Zhang, Qian-Yan He, Jie Liu, Jun-Lei Chang, Yi Yang, Zhen-Ni Guo   +8 more
doaj   +3 more sources

Lipocalin-2 and Cerebral Stroke

Frontiers in Molecular Neuroscience, 2022
Stroke is a common and devastating disease with an escalating prevalence worldwide. The known secondary injuries after stroke include cell death, neuroinflammation, blood-brain barrier disruption, oxidative stress, iron dysregulation, and neurovascular ...
Chao Luo, Shuai Zhou, Shuai Zhou, Shi Yin, Lipeng Jian, Pengren Luo, Jigeng Dong, Erheng Liu   +7 more
doaj   +3 more sources

AI-assisted design of ligands for lipocalin-2. [PDF]

Front Immunol
Introduction Lipocalin-2 (LCN2) is an acute-phase glycoprotein whose upregulation is associated with blood–brain-barrier breakdown and neuroinflammation, making it a potential diagnostic and therapeutic target. Methods We developed an ...
Sgrignani J, Buscarini S, Locatelli P, Guerra C, Furlan A, Chen Y, Zoppi G, Cavalli A.   +7 more
europepmc   +3 more sources

Lipocalin-2 and intestinal diseases. [PDF]

World J Gastroenterol
Dysfunction of the intestinal barrier is a prevalent phenomenon observed across a spectrum of diseases, encompassing conditions such as mesenteric artery dissection, inflammatory bowel disease, cirrhosis, and sepsis. In these pathological states, the integrity of the intestinal barrier, which normally serves to regulate the selective passage of ...
Zhang ZX, Peng J, Ding WW.
europepmc   +3 more sources

Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis

Journal of Inflammation Research, 2022
Kaixuan Ren, Yumin Xia Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, People’s Republic of ChinaCorrespondence: Yumin Xia, Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong
Yumin Xia, Ren Kaixuan
exaly   +2 more sources

Role of lipocalin-2 in amyotrophic lateral sclerosis. [PDF]

Front Aging Neurosci
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized pathologically by degeneration of upper and lower motor neurons, ultimately leading to muscle weakness and respiratory failure. Lipocalin-2 (LCN2) is a secreted protein involved in lipid transport that plays a key role in inflammatory responses and the ...
Wang Z, Cao W, Fan D.
europepmc   +3 more sources

Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis

Frontiers in Immunology, 2018
Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed de novo by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial ...
Joshua Woodworth, Allan Randrup Thomsen, Claus Moser   +2 more
exaly   +3 more sources

Association of Urinary Lipocalin-2 with Lupus Nephritis [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Objective(s): Lupus nephritis (LN) is the main cause of mortality and disability in systemic lupus erythematosus (SLE) patients. Therefore, utilizing a reliable and non-invasive method for serial measurements of renal function seems to be necessary. The
Farzaneh Sharifipour, Abbasali Zeraati, Maryam Sahebari, Mohammadreza Hatef, Masih Naghibi, Zahra Rezaieyazdi, Mahmoud Mahmoudi, Amir Abbas Azarian, Zahra Mirfeizi, Katayoun Samadi   +9 more
doaj   +3 more sources

Lipocalin 2 receptors: facts, fictions, and myths

Frontiers in Immunology, 2023
The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in part is associated with gelatinase from neutrophils. This protein shows a high degree of sequence similarity with the deduced sequences of rat α2-microglobulin ...
Sarah K. Schröder, Natalie Gasterich, Sabine Weiskirchen, Ralf Weiskirchen   +3 more
doaj   +3 more sources

Circulating lipocalin-2 across the adult lifespan. [PDF]

JBMR Plus
Abstract Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play in pathological states, we first need to elucidate the relationship between circulating LCN2 with indices of cardio-metabolic ...
Bauer C, Smith C, Vogrin S, Palmer AS, Woessner M, Landen S, Jacques M, Byrnes E, Eynon N, Sim M, Lewis JR, Levinger I.   +11 more
europepmc   +4 more sources