Results 41 to 50 of about 35,244 (209)

Anemia upregulates lipocalin 2 in the liver and serum [PDF]

Blood Cells, Molecules, and Diseases, 2008
Lipocalin 2 (Lcn2), a mammalian protein that is expressed and secreted in various pathologic states, binds siderophores, which are high-affinity iron chelators. Besides its role in limiting iron availability to pathogens in the setting of bacterial infection, Lcn2:siderophore complexes can also deliver iron to cells.
Wenlei, Jiang, Marco, Constante, Manuela M, Santos   +2 more
openaire   +2 more sources

Lipocalin 2: A New Antimicrobial in Mast Cells [PDF]

International Journal of Molecular Sciences, 2019
Mast cells (MCs) play a significant role in the innate immune defense against bacterial infection through the release of cytokines and antimicrobial peptides. However, their antimicrobial function is still only partially described. We therefore hypothesized that MCs express additional antimicrobial peptides.
Yu-Ling Chang, Zhenping Wang, Satomi Igawa, Jae Eun Choi, Tyler Werbel, Anna Di Nardo   +5 more
openaire   +4 more sources

Plasma lipocalin‐2 levels in the preclinical stage of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Lipocalin‐2 is an acute‐phase protein with pleotropic functions that has been implicated in several diseases including Alzheimer's disease (AD). However, it is unknown if circulating lipocalin‐2 levels are altered in the preclinical stage of
Emily Eruysal, Lisa Ravdin, Hooman Kamel, Costantino Iadecola, Makoto Ishii   +4 more
doaj   +1 more source

Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers

Alzheimer’s Research & Therapy, 2022
Background Lipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in response to vascular and other brain injury, as well as in Alzheimer’s disease in reactive microglia and
Peter Hermann, Anna Villar-Piqué, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Inês Baldeiras, Joachim Riggert, Inga Zerr, Franc Llorens   +13 more
doaj   +1 more source

Lipocalin‐2 as a prognostic biomarker and its association with systemic inflammation in small cell lung cancer

Thoracic Cancer
Background Systemic inflammation is believed to contribute to small cell lung cancer (SCLC) progression, but the underlying relationship remains unclear.
Se‐Il Go, Jung Wook Yang, Woo Je Lee, Eun Jeong Jeong, Sungwoo Park, Gyeong‐Won Lee   +5 more
doaj   +1 more source

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice

Stem Cells International, 2023
Background. Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack ...
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang   +8 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

Frontiers in Cellular Neuroscience, 2012
Multiple sclerosis is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first episode is still lacking, but since early treatment leads to better prognosis, the search for early ...
Fernanda eMarques, Fernanda eMarques, Sandro D Mesquita, Sandro D Mesquita, Joao C Sousa, Joao C Sousa, Giovanni eCoppola, Fuying eGao, Daniel H Geschwind, Sandra eColumba-cabezas, Francesca eAloisi, Matilda eDegna, João J Cerqueira, João J Cerqueira, João J Cerqueira, Nuno eSousa, Nuno eSousa, Nuno eSousa, Margarida eCorreia-Neves, Margarida eCorreia-Neves, Joana A Palha, Joana A Palha, Joana A Palha   +22 more
doaj   +1 more source

Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease

The FASEB Journal, 2012
ABSTRACT Alzheimer's disease (AD) is associated with an altered immune response, resulting in chronic increased inflammatory cytokine production with a prominent role of TNF‐α. TNF‐α signals are mediated by two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Signaling through TNFR2 is associated with
Naudé, Petrus J W, Nyakas, Csaba, Eiden, Lee E, Ait-Ali, Djida, van der Heide, Ragna, Engelborghs, Sebastiaan, Luiten, Paul G M, De Deyn, Peter P, den Boer, Johan A, Eisel, Ulrich L M   +9 more
openaire   +5 more sources

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source