Results 41 to 50 of about 24,464,671 (254)

Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)

Arthritis Research & Therapy, 2020
Background Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of inflammatory bowel diseases (IBD) and ankylosing spondylitis (AS).
Aifeng Lin, Robert D. Inman, Catherine J. Streutker, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui, Florence W. L. Tsui   +6 more
doaj   +1 more source

The Neutrophil Gelatinase-associated lipocalin (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells [PDF]

, 2008
NF-κB is constitutively activated in primary human thyroid tumors, particularly in those of anaplastic type. The inhibition of NF-κB activity in the human anaplastic thyroid carcinoma cell line, FRO, leads to an increased susceptibility to ...
Iannetti, Alessio
core   +1 more source

Adipokines resistin and lipokalin-2 and its role in the pathogenesis of polycystic ovary syndrome and metabolic syndrome [PDF]

Medičnì Perspektivi, 2013
Adipose tissues hormones resistin and lipocalin -2 play an important role in the regulation of lipid and carbohydrate metabolism, inflammation and immune disorders, fertility and reproductive mechanisms.
Voronenko N.Yu.
doaj   +3 more sources

Association between FGF19, FGF21 and lipocalin-2, and diabetes progression in PCOS

Endocrine Connections, 2021
Women with polycystic ovary syndrome (PCOS) have an increased risk of developing type 2 diabetes. FGF19, FGF21 and lipocalin-2 have emerged as important markers of metabolic risk.
Feifei Cheng, Noel Yat Hey Ng, Claudia Ha Ting Tam, Yuying Zhang, Cadmon King Poo Lim, Guozhi Jiang, Alex Chi Wai Ng, Tiffany Tse Ling Yau, Lai Ping Cheung, Aimin Xu, Juliana C N Chan, Ronald C W Ma   +11 more
doaj   +1 more source

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis [PDF]

The Journal of Neuroscience, 2009
Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. In response to a brain injury, astrocytes proliferate and become hypertrophic with an increased expression of intermediate filament proteins.
Shinrye, Lee, Jae-Yong, Park, Won-Ha, Lee, Ho, Kim, Hae-Chul, Park, Kiyoshi, Mori, Kyoungho, Suk   +6 more
openaire   +2 more sources

The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer

BMC Cancer, 2012
Background Although a number of experimental studies have suggested the role of lipocalin-2 (LCN2) and matrix metalloproteinase-9 (MMP-9) in breast cancer progression, limited numbers of epidemiological studies have examined the relationship between the ...
Sung Hyuna, Choi Ji-Yeob, Lee Sang-Ah, Lee Kyoung-Mu, Han Sohee, Jeon Sujee, Song Minkyo, Lee Yunhee, Park Sue K, Yoo Keun-Young, Noh Dong-Young, Ahn Sei-Hyun, Kang Daehee   +12 more
doaj   +1 more source

The Potential Role of Chemerin, Lipocalin 2, and Apelin in the Diagnosis and Pathophysiology of Gestational Diabetes Mellitus

Journal of Diabetes Research, 2021
The exact role of adipokines in the pathogenesis of gestational diabetes mellitus (GDM) still remains not fully clear, and multiple studies have analyzed their potential contribution to the pathophysiology of this pregnancy complication.
Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Dominik Dłuski, Maciej Kamiński, Agnieszka Mierzyńska, Bożena Leszczyńska-Gorzelak   +5 more
doaj   +1 more source

Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate NaIO₃-Induced Dry AMD by Delivering miR-486-3p to Inhibit Lipocalin-2-Mediated Ferroptosis. [PDF]

MedComm (2020)
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Li Z, Zhao T, Ye L, Li R, Tian H, Liao R, Huang L.   +6 more
europepmc   +2 more sources

Plasma lipocalin‐2 levels in the preclinical stage of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Lipocalin‐2 is an acute‐phase protein with pleotropic functions that has been implicated in several diseases including Alzheimer's disease (AD). However, it is unknown if circulating lipocalin‐2 levels are altered in the preclinical stage of
Emily Eruysal, Lisa Ravdin, Hooman Kamel, Costantino Iadecola, Makoto Ishii   +4 more
doaj   +1 more source

Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers

Alzheimer’s Research & Therapy, 2022
Background Lipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in response to vascular and other brain injury, as well as in Alzheimer’s disease in reactive microglia and
Peter Hermann, Anna Villar-Piqué, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Inês Baldeiras, Joachim Riggert, Inga Zerr, Franc Llorens   +13 more
doaj   +1 more source