Results 61 to 70 of about 24,464,671 (254)

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

Frontiers in Cellular Neuroscience, 2012
Multiple sclerosis is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first episode is still lacking, but since early treatment leads to better prognosis, the search for early ...
Fernanda eMarques, Fernanda eMarques, Sandro D Mesquita, Sandro D Mesquita, Joao C Sousa, Joao C Sousa, Giovanni eCoppola, Fuying eGao, Daniel H Geschwind, Sandra eColumba-cabezas, Francesca eAloisi, Matilda eDegna, João J Cerqueira, João J Cerqueira, João J Cerqueira, Nuno eSousa, Nuno eSousa, Nuno eSousa, Margarida eCorreia-Neves, Margarida eCorreia-Neves, Joana A Palha, Joana A Palha, Joana A Palha   +22 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Salivary lipocalin family proteins from Panstrongylus chinai, a vector of Chagas disease

Data in Brief, 2017
The dataset in this report is related to the research article with the title: “Salivary gland transcripts of the kissing bug, Panstrongylus chinai, a vector of Chagas disease” (Kato et al., 2017) [1].
Hirotomo Kato, Ryan C. Jochim, Eduardo A. Gomez, Shunsuke Tsunekawa, Jesus G. Valenzuela, Yoshihisa Hashiguchi   +5 more
doaj   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Lipocalin 2 as a clinical significance in rheumatoid arthritis

Central European Journal of Immunology, 2017
<b>Aim of the study</b>: In this study, serum lipokalin 2 (LCN-2) levels and its clinical and radiological significance in patients with rheumatoid arthritis was evaluated.<br /> <b>Material and methods</b>: The study enrolled 37 patients with RA and 34 healthy controls.
Arif Gulkesen, Gurkan Akgol, Ahmet K. Poyraz, Suleyman Aydin, Affan Denk, Tulay Yildirim, Arzu Kaya   +6 more
openaire   +3 more sources

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Deamidated lipocalin-2 induces endothelial dysfunction in dietary obese mice

, 2013
INTRODUCTION: Lipocalin-2 is a pro-inflammatory adipokine implicated in the pathogenesis of obesity-associated cardiovascular diseases. The expression and production of lipocalin-2 is augmented in obese humans and animals.
Wang, Y
core   +1 more source

Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

, 2023
Summary: Mitochondrial dysfunction is a critical process in renal epithelial cells upon kidney injury. While its implication in kidney disease progression is established, the mechanisms modulating it remain unclear.
Nguyen, Clément, Alves Teixeira, Maraiza, Morgan Gallazzini, Fabiola Terzi, Maraiza Alves Teixeira, Marques, Eloïse, Eloïse Marques, Clément Nguyen, Terzi, Fabiola, Gallazzini, Morgan   +9 more
core   +1 more source

Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis

Data in Brief, 2017
The data presented in this brief report support the research article “Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis” [1, doi: 10.1016/j.bbadis.2017.04.006]. We tested whether the absence of Lipocalin-
Anastasia Asimakopoulou, Erawan Borkham-Kamphorst, Eddy Van de Leur, Ralf Weiskirchen   +3 more
doaj   +1 more source