Results 51 to 60 of about 24,464,671 (254)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice

Stem Cells International, 2023
Background. Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack ...
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang   +8 more
doaj   +1 more source

Anemia upregulates lipocalin 2 in the liver and serum [PDF]

Blood Cells, Molecules, and Diseases, 2008
Lipocalin 2 (Lcn2), a mammalian protein that is expressed and secreted in various pathologic states, binds siderophores, which are high-affinity iron chelators. Besides its role in limiting iron availability to pathogens in the setting of bacterial infection, Lcn2:siderophore complexes can also deliver iron to cells.
Wenlei, Jiang, Marco, Constante, Manuela M, Santos   +2 more
openaire   +2 more sources

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Lipocalin 2 promotes breast cancer progression [PDF]

Proceedings of the National Academy of Sciences, 2009
Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, and we identify the mechanisms underlying this function. We first found that Lcn2 levels were consistently associated with invasive breast cancer in human tissue and urine samples.
Jiang, Yang, Diane R, Bielenberg, Scott J, Rodig, Robert, Doiron, Matthew C, Clifton, Andrew L, Kung, Roland K, Strong, David, Zurakowski, Marsha A, Moses   +8 more
openaire   +2 more sources

Lipocalin-2 expression and function in pancreatic diseases

Pancreatology, 2020
Lipocalin-2 (LCN2) is a secreted molecule, expressed in various cell types, that is involved in the progression of numerous diseases and disorders. The biological functions and expression levels of LCN2 in diseases including pancreatic cancer, pancreatitis (acute and chronic), and diabetes mellitus, suggest the potential role of LCN2 as a biomarker and/
Kristyn Gumpper, Andrew William Dangel, Valentina Pita-Grisanti, Somashekar G. Krishna, Luis F. Lara, Thomas Mace, Georgios I. Papachristou, Darwin L. Conwell, Phil A. Hart, Zobeida Cruz-Monserrate   +9 more
openaire   +3 more sources

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Evaluation of the expression of matrix metalloproteinase 9 and neutrophil gelatinase associated lipocalin in serum, urine and tumoral tissues of female dogs suffering from mammary gland tumors [PDF]

, 2013
In human medicine, it has been shown recently that the level of expression of matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL) in serum, urine, and breast tissue were significantly increased in patients with breast
Belot, Guillaume
core  

Lipocalin-2 gene expression during liver regeneration after partial hepatectomy in rats

, 2014
Background: Lipocalin-2 (Lcn2) is related to cell proliferation. We studied Lcn2 gene expression during liver regeneration after partial hepatectomy (PH). Methods: Male Wistar rats were sacrificed before and 2, 4, 6, 12, 24, 72 h, 7 days after 70% or 40%
Lai, Hong-Shiee;Wu, Yao-Ming;Lai, Shuo-Lun;Lin, Wen-Hsi, 賴鴻緒   +1 more
core   +1 more source

Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease

The FASEB Journal, 2012
ABSTRACT Alzheimer's disease (AD) is associated with an altered immune response, resulting in chronic increased inflammatory cytokine production with a prominent role of TNF‐α. TNF‐α signals are mediated by two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Signaling through TNFR2 is associated with
Naudé, Petrus J W, Nyakas, Csaba, Eiden, Lee E, Ait-Ali, Djida, van der Heide, Ragna, Engelborghs, Sebastiaan, Luiten, Paul G M, De Deyn, Peter P, den Boer, Johan A, Eisel, Ulrich L M   +9 more
openaire   +5 more sources