Results 31 to 40 of about 24,464,671 (254)

Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin [PDF]

, 2009
OBJECTIVE - Lipocalin-2, a novel adipokine, has been shown to be elevated in obese, insulin-resistant, and diabetic Subjects. We therefore sought to study the ex vivo and in vivo effects of insulin on lipocalin-2 levels in humans. RESEARCH DESIGN AND
Randeva, Harpal S., Shan, Xiaoye, Tan, Bee K., Levandowski, Krzysztof C., Syed, Farhatullah, O'Hare, J. Paul, Adya, Raghu   +6 more
core   +1 more source

Lipocalin-2 is an anorexigenic signal in primates

eLife, 2020
In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase serum LCN2 levels in persons with normal or overweight, but not in individuals with obesity. Postprandial LCN2 serum levels correlate inversely with hunger sensation in challenged subjects.
Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni   +25 more
openaire   +3 more sources

Lipocalin‐2 ameliorates granulocyte functionality [PDF]

European Journal of Immunology, 2012
Attraction of neutrophils to sites of infection or tissue injury is an essential prerequisite for an efficient innate immune response. Herein, we provide novel evidence that the antimicrobial protein, neutrophil gelatinase associated lipocalin (24p3 or lipocalin‐2, Lcn2) is a central regulator of this process. Lcn2 is produced by several cell types but
Andrea, Schroll, Kathrin, Eller, Clemens, Feistritzer, Manfred, Nairz, Thomas, Sonnweber, Patrizia A, Moser, Alexander R, Rosenkranz, Igor, Theurl, Guenter, Weiss   +8 more
openaire   +2 more sources

No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.

PLoS ONE, 2012
NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of breast cancer as determined both
Elisabeth P Cramer, Andreas Glenthøj, Mattias Häger, Anna Juncker-Jensen, Lars H Engelholm, Eric Santoni-Rugiu, Leif R Lund, Ole D Laerum, Jack B Cowland, Niels Borregaard   +9 more
doaj   +1 more source

The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

Reproductive Biology and Endocrinology, 2010
Background Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary
Kalaitzakis Emmanuil, Delkos Dimitrios, Tsourdi Elena, Kandaraki Eleni A, Koiou Ekaterini, Tziomalos Konstantinos, Panidis Dimitrios, Katsikis Ilias   +7 more
doaj   +1 more source

Expression and Clinical Significance of Lipocalin-2 in the Serum of Lung Cancer Patients

Chinese Journal of Lung Cancer, 2021
Background and objective Lung cancer is the highest incidence of cancer in the world, which seriously threatens human health. Early diagnosis and treatment of lung cancer is particularly important for the survival of lung cancer patients.
Liming FAN, Yuan TIAN, Ying SUN, Zhidong HU   +3 more
doaj   +1 more source

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]

, 2013
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
O'Hara, J, Smith, C, Piper, R, Begley, J, Yarker, J, Boos, C, Turner, S, Stacey, M, King, R, Mellor, A, Hooper, T, Woods, DR   +11 more
core   +1 more source

Plasma Neutrophil Gelatinase-associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infection [PDF]

Childhood Kidney Diseases, 2021
Purpose We aimed to study the association of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and leukocyte differential count in children with febrile urinary tract infection (UTI).
Min Hwa Son, Hyung Eun Yim, Kee Hwan Yoo
doaj   +1 more source

Lipocalin 2 promotes lung metastasis of murine breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2008
Background Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis. However, the roles of lipocalin 2 in breast cancer formation and metastasis have not been clearly
Mi Wenyi, Xu Liang, Yang Jing, Gu Yuchao, Shi Han, Yu Wengong   +5 more
doaj   +1 more source

Plasma lipocalin‐2 levels in pregnancy

Acta Obstetricia et Gynecologica Scandinavica, 2011
AbstractObjective. To evaluate plasma levels of lipocalin‐2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective case–control study. Setting. University hospital. Population. Pregnant women with pre‐pregnancy body mass index >25kg/m2 (overweight; n=29) and body mass index <25kg/m2 (n ...
Cesur, Semra, Yucel, Aykan, Noyan, Volkan, Sagsoz, Nevin   +3 more
openaire   +2 more sources