Results 11 to 20 of about 35,244 (209)

The role of inflammatory biomarkers RBP4, Lipocalin-2, and hsCRP in prediabetes and type 2 diabetes mellitus [PDF]

Journal of Medical Biochemistry
Background: Adipocytokines, along with macrophages infiltrating adipose tissue, contribute to chronic low-grade inflammation, which leads to insulin resistance and type 2 diabetes.
Ornek Diker Vesile, Serin Ozden, Yorulmaz Ertug Ebru, Baytekin Ozlem, Oguz Osman, Güvenen Güvenç   +5 more
doaj   +2 more sources

Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score

Prostate Cancer, 2021
Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and ...
M. Hakan Ulusoy, Yalcin Cirak, Yasemen Adali   +2 more
doaj   +1 more source

Lipocalin-2 is associated with FGF23 in WNT1 and PLS3 osteoporosis

Frontiers in Endocrinology, 2022
BackgroundThe pathogenic mechanisms of early-onset osteoporosis caused by WNT1 and PLS3 mutations are incompletely understood and diagnostic biomarkers of these disorders are limited.
Petra Loid, Petra Loid, Petra Loid, Helena Hauta-alus, Helena Hauta-alus, Helena Hauta-alus, Helena Hauta-alus, Outi Mäkitie, Outi Mäkitie, Outi Mäkitie, Outi Mäkitie, Per Magnusson, Riikka E. Mäkitie, Riikka E. Mäkitie, Riikka E. Mäkitie   +14 more
doaj   +1 more source

Increased plasma lipocalin-2 levels correlate with disease severity and may be a marker of acute inflammatory response in patients with psoriasis

Dermatology Reports, 2022
Background: More than a skin disease, psoriasis is also considered a systemic disorder. Lipocalin- 2, an adipokine, may be a link between psoriasis and systemic inflammation.
Chuyen Thi Hong Nguyen, Oanh Phan Tram Nguyen   +1 more
doaj   +1 more source

Lipocalin 2 – mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals

Frontiers in Endocrinology, 2023
ContextThe bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway.ObjectiveWe aimed to (i) detect variants in the lipocalin-2 gene (LCN2) which are relevant for body weight regulation and ...
Yiran Zheng, Yiran Zheng, Luisa Sophie Rajcsanyi, Luisa Sophie Rajcsanyi, Manuela Kowalczyk, Johanna Giuranna, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stefan Ehrlich, Stephan Zipfel, Stephan Zipfel, Katrin Giel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Saad Al-Lahham, Johannes Hebebrand, Johannes Hebebrand, Dagmar Fuhrer, Dagmar Fuhrer, Susanne Tan, Denise Zwanziger, Triinu Peters, Triinu Peters, Anke Hinney, Anke Hinney   +29 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes. [PDF]

PLoS ONE, 2013
The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders.
Yang Xiao, Aimin Xu, Xiaoyan Hui, Pengcheng Zhou, Xing Li, Hui Zhong, Weili Tang, Gan Huang, Zhiguang Zhou   +8 more
doaj   +1 more source

Lipocalin-2 and neutrophil activation in pancreatic cancer cachexia

Frontiers in Immunology, 2023
BackgroundCancer cachexia is a multifactorial syndrome characterized by body weight loss and systemic inflammation. The characterization of the inflammatory response in patients with cachexia is still limited.
Min Deng, Merel R. Aberle, Annemarie A. J. H. M. van Bijnen, Gregory van der Kroft, Gregory van der Kroft, Kaatje Lenaerts, Ulf P. Neumann, Ulf P. Neumann, Georg Wiltberger, Frank G. Schaap, Frank G. Schaap, Steven W. M. Olde Damink, Steven W. M. Olde Damink, Sander S. Rensen   +13 more
doaj   +1 more source

Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP

Life, 2023
Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by viruses of the Orthohantavirus genus. This syndrome is characterized by renal and cardiopulmonary implications detectable with different biomarkers. Here, we explored the
Lidija Cvetko Krajinović, Kristian Bodulić, Renata Laškaj, Branka Žibrat, Petra Svoboda Karić, Ivan-Christian Kurolt, Mihaela Kordun, Antea Topić, Rok Čivljak, Tomislava Skuhala, Alemka Markotić   +10 more
doaj   +1 more source