Results 71 to 80 of about 24,464,671 (254)

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans

, 2007
Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related ...
Wang, Y, Hoo, RLC, Tso, AWK, Nelson MS Wat, Wat, NMS, Aimin Xu, Lam, KSL, Karen S L Lam, Gary Sweeney, Wing-Sun Chow, Xu, JY, Jian Yu Xu, Ruby LC Hoo, Sweeney, G, Jialiang Zhang, Annette WK Tso, Yu Wang, Edward W Kraegen, Kraegen, EW, Xu, A, Zhang, J, Chow, WS   +21 more
core   +1 more source

Lipocalin 2: A multifaceted modulator of human cancer [PDF]

Cell Cycle, 2009
Lipocalin 2 (Lcn2), a member of the lipocalin family that transports small lipophilic ligands, has gained recent attention as both a potential biomarker and a modulator of human cancers. Here we describe recent findings of the functions of Lcn2 in breast cancer and the potential mechanisms that underlie its actions.
Jiang, Yang, Marsha A, Moses
openaire   +2 more sources

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Altered IL-3 and lipocalin-2 levels are associated with the pathophysiology of major depressive disorder: a case-control study

BMC Psychiatry, 2023
Background Major Depressive Disorder (MDD) is a common mental ailment and is the primary reason for disability. It manifests a severe impact on moods, thoughts, and physical health.
Mst. Sarmin Akter, Faisal Abdullah Emon, Zabun Nahar, MMA Shalahuddin Qusar, Sardar Mohammad Ashraful Islam, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam   +7 more
doaj   +1 more source

Disposal of iron by a mutant form of lipocalin 2 [PDF]

Nature Communications, 2016
AbstractIron overload damages many organs. Unfortunately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes. Here we show that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resulting in urinary excretion.
Barasch, Jonathan, Hollmen, Maria, Deng, Rong, Hod, Eldad A, Rupert, Peter B, Abergel, Rebecca J, Allred, Benjamin E, Xu, Katherine, Darrah, Shaun F, Tekabe, Yared, Perlstein, Alan, Wax, Rebecca, Bruck, Efrat, Stauber, Jacob, Corbin, Kaitlyn A, Buchen, Charles, Slavkovich, Vesna, Graziano, Joseph, Spitalnik, Steven L, Bao, Guanhu, Strong, Roland K, Qiu, Andong   +21 more
openaire   +4 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Lipocalin 2: A New Antimicrobial in Mast Cells [PDF]

International Journal of Molecular Sciences, 2019
Mast cells (MCs) play a significant role in the innate immune defense against bacterial infection through the release of cytokines and antimicrobial peptides. However, their antimicrobial function is still only partially described. We therefore hypothesized that MCs express additional antimicrobial peptides.
Yu-Ling Chang, Zhenping Wang, Satomi Igawa, Jae Eun Choi, Tyler Werbel, Anna Di Nardo   +5 more
openaire   +4 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source