Results 51 to 60 of about 16,730 (235)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Salivary lipocalin family proteins from Panstrongylus chinai, a vector of Chagas disease

Data in Brief, 2017
The dataset in this report is related to the research article with the title: “Salivary gland transcripts of the kissing bug, Panstrongylus chinai, a vector of Chagas disease” (Kato et al., 2017) [1].
Hirotomo Kato, Ryan C. Jochim, Eduardo A. Gomez, Shunsuke Tsunekawa, Jesus G. Valenzuela, Yoshihisa Hashiguchi   +5 more
doaj   +1 more source

Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

Molecular Neurodegeneration, 2015
A diverse set of neurodegenerative disorders are caused by abnormal extensions of polyglutamine (poly-Q) stretches in various, functionally unrelated proteins. A common feature of these diseases is altered proteostasis. Autophagy induction is part of the
Manuela del Caño-Espinel, Judith R Acebes, D. Sánchez, M. Ganfornina   +3 more
semanticscholar   +1 more source

Novel OBP genes similar to hamster Aphrodisin in the bank vole, Myodes glareolus

BMC Genomics, 2010
Background Chemical communication in mammals involves globular lipocalins that protect and transport pheromones during their passage out of the body.
Šandera Martin, Šedo Ondřej, Ryba Štěpán, Zdráhal Zbyněk, Stopková Romana, Stopka Pavel   +5 more
doaj   +1 more source

Proteomic analysis of the mouse sperm acrosome - towards an understanding of an organelle with diverse functionality

European Journal of Cell Biology, 2023
The acrosome located within the mammalian sperm head is essential for successful fertilization, as it enables the sperm to penetrate the extracellular layers of the oocyte and fuse with oolemma.
Tereza Otčenášková, Eliška Macíčková, Jana Vondráková, Michaela Frolíková, Katerina Komrskova, Romana Stopková, Pavel Stopka   +6 more
doaj   +1 more source

Overexpression of Lipocalins and Pro-Inflammatory Chemokines and Altered Methylation of PTGS2 and APC2 in Oral Squamous Cell Carcinomas Induced in Rats by 4-Nitroquinoline-1-Oxide

PLoS ONE, 2015
Oral squamous cell carcinomas (OSCC) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers.
Xinjian Peng, Wenping Li, W. Johnson, Karen E. O. Torres, D. Mccormick   +4 more
semanticscholar   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, EarlyView.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

Characterization of mammalian Lipocalin UTRs in silico: Predictions for their role in post-transcriptional regulation.

PLoS ONE, 2019
The Lipocalin family is a group of homologous proteins characterized by its big array of functional capabilities. As extracellular proteins, they can bind small hydrophobic ligands through a well-conserved β-barrel folding.
Andres Mejias, Sergio Diez-Hermano, Maria D Ganfornina, Gabriel Gutierrez, Diego Sanchez   +4 more
doaj   +1 more source

Análisis in silico de lipocalinas de perro, gato, caballo, vaca, hámster y gallina. Posible efecto en el estudio de las enfermedades alérgicas

Revista Alergia México, 2016
Background: Lipocalins seem to explain the cross-reactivity between some pets like cat and dog. However, little has been studied its role in other animals and its possible clinical impact in allergy diseases.
Andrés Sánchez, Ricardo Cardona, Jorge Sánchez   +2 more
doaj   +1 more source