Generation of NADPH and the formation of lipofuscin fluorophore precursors in human rod photoreceptors. [PDF]
J Biol ChemAdler L, Chen C, Boyer NP, Koutalos Y.
europepmc +1 more source
6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in <i>C. elegans</i>. [PDF]
ToxicsWu J, Bian Q, Wang D.
europepmc +1 more source
Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism. [PDF]
Front Aging NeurosciXiao Y +8 more
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Ginseng Oligopeptides Promote Longevity and Enhance Stress Resistance in <i>Caenorhabditis elegans</i> via the DAF-16/FOXO Pathway. [PDF]
Antioxidants (Basel)Du Q, Zhang Y, Guo X, Cai M, Li Y, Xu M.
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Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy. [PDF]
NeurophotonicsAbdelhakeem AA +8 more
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Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity.
Alexei Terman, Ulf T Brunk
exaly +4 more sources
Abstract: One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins ...
Tilman Grune
exaly +3 more sources
Lipofuscin and lipofuscin-like substances
Chemistry and Physics of Lipids, 1987Lipofuscin is defined as being a yellowish brown, lipid-rich, heterogeneous, cytoplasmic granular pigment emitting an intense yellow autofluorescence when excited with ultraviolet light, which accumulates in various tissues of animals during their aging.
Toshiyuki Miura +2 more
exaly +3 more sources
An overview of the melanins and lipofuscin is presented, taking an integrating account of their morphological relationships and chemical characteristics wherever possible. This has required inclusion of the ommochromes, the schlerotizing process, and consideration of related neurotransmitters. A number of questions are raised and commented upon.
M H, Hack, F M, Helmy
openaire +2 more sources