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The Senolytic Drug Navitoclax Protects the Brain After Experimental Ischemic Stroke. [PDF]
Pharmaceuticals (Basel)Falahatgaroshibi D +6 more
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Network Pharmacology-Based Study of Citrus medica L. Ethanol Extract Combating Obesity in Caenorhabditis elegans via Dual Action on AAK-2/NHR-49 and MDT-15/SBP-1 Pathways. [PDF]
Chem BiodiversZhao F +7 more
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Irradiation with a mixed heavy ion beam induces ovarian follicle loss and dose-dependent mixed ovarian tumor development. [PDF]
Biol ReprodLeon Parada KN +7 more
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Cyclopyranil (Pesticides). [PDF]
Food Saf (Tokyo)Food Safety Commission of Japan.
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International Journal of Biochemistry and Cell Biology, 2004
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity.
Alexei Terman, Ulf T Brunk
exaly +4 more sources
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity.
Alexei Terman, Ulf T Brunk
exaly +4 more sources
Lipofuscin and lipofuscin-like substances
Chemistry and Physics of Lipids, 1987Lipofuscin is defined as being a yellowish brown, lipid-rich, heterogeneous, cytoplasmic granular pigment emitting an intense yellow autofluorescence when excited with ultraviolet light, which accumulates in various tissues of animals during their aging.
K Aibara
exaly +3 more sources
Annals of the New York Academy of Sciences, 2007
Abstract: One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins ...
Tilman Grune
exaly +3 more sources
Abstract: One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins ...
Tilman Grune
exaly +3 more sources