Results 131 to 140 of about 17,675 (181)

Lipofuscin in Cardiac Hypertrophy

Beiträge zur Pathologie, 1972
Summary Quantitative investigations on the lipofuscin content in human hearts from various weight classes should allow us to conclude whether or not a correlation exists between pigment content and the degree of cardiac hypertrophy. The investigations were performed on 7 μ thick tissue sections from 12 autopsied hearts, and included microscopic ...
W, Sandritter, B, Bierfreund, F, Pannen, C P, Adler   +3 more
openaire   +2 more sources

A2E and Lipofuscin

2015
Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration.
Rosalie K, Crouch, Yiannis, Koutalos, Masahiro, Kono, Kevin, Schey, Zsolt, Ablonczy   +4 more
openaire   +2 more sources

The photoreactivity of ocular lipofuscin

Photochemical & Photobiological Sciences, 2004
Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity.
Boulton, M, Rózanowska, M, Rözanowski, B, Wess, Tim J   +3 more
openaire   +3 more sources

Lipofuscin and transsynaptic degeneration

Virchows Archiv A Pathological Anatomy and Histology, 1978
The periodic acid Schiff reaction was applied to neurones in the Lateral Geniculate Body (L.G.B.) of a series of normal and blind patients over a wide age range. The quantity of the reaction product was determined as a measure of lipofuscin which was found to increase linearly with age in the L.G.B. neurones.
C L, Scholtz, A, Brown
openaire   +2 more sources

Lipofuscin: formation, effects and role of macroautophagy

Redox Biology, 2013
Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin.
Annika Hohn, Tilman Grune
exaly   +4 more sources

Mitochondrial Lipofuscin and Thermomitochondrial Lipofuscin in Homogenates of Rat Organs

Biophysics, 2019
Abstract—The amounts of lipofuscin (age pigment) were compared in four organs of rats: the liver, the kidney, the heart muscle, and the brain, as well as in a suspension of ghosts of hepatic mitochondria. It was shown that liver lipofuscin, which absorbs UV light at 360 nm and fluoresces at 460 nm, is predominantly formed due to mitochondrial processes.
A. V. Chaplygina, N. L. Vekshin
openaire   +1 more source

Catabolism of the Lipofuscin Cycloretinal by MsP1

Biochemistry, 2022
Age-related macular degeneration (AMD) is a debilitating eye disease that tends to affect people over the age of 55. Lipofuscins are autofluorescent, toxic byproducts of the visual cycle thought to contribute toward the progression of the disease. Targeting the accumulation of lipofuscin through catabolism may serve as a method for the early treatment ...
Irum Perveen, Brett A. Johnson, Vishruth Gowda, Brendan Foley, Stephanie Okezie, Mackenzie O’Brien, Coran M. H. Watanabe   +6 more
openaire   +2 more sources

Lipofuscin and Macular Degeneration

Nutrition Reviews, 2003
The accumulation of the autofluorescent pigment lipofuscin in the retina that occurs with aging has been explained as a side effect of the visual cycle. It occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the discs of the rod outer segments, and is followed by uptake into retinal pigment ...
openaire   +2 more sources

Action spectra for the photoconsumption of oxygen by human ocular lipofuscin and lipofuscin extracts

Archives of Biochemistry and Biophysics, 2002
The action spectra for the photoconsumption of oxygen by lipofuscin isolated from human retinal pigment epithelium cells and liposomal suspensions containing extracts of lipofuscin are reported. The lipofuscin and lipofuscin extract action spectra are similar, demonstrating the phototoxic constituents of lipofuscin are present in the lipofuscin solvent
Anna, Pawlak, Małgorzata, Rózanowska, Mariusz, Zareba, Laura E, Lamb, John D, Simon, Tadeusz, Sarna   +5 more
openaire   +2 more sources

The effect of lipofuscin on cellular function

Mechanisms of Ageing and Development, 1983
The neurons of the supraoptic nucleus of male C57BL/Icrfat mice at 6 or 28 months of age were examined from normally hydrated, osmotically loaded and osmotically loaded-rehydrated animals. Using quantitative morphological techniques, a reduction in the concentration of lipofuscin in the neurons was observed in osmotically loaded mice at both ages, and ...
Davies, I, Fotheringham, A, Roberts, C
openaire   +2 more sources