Results 151 to 160 of about 17,764 (195)
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Mitochondrial Lipofuscin and Thermomitochondrial Lipofuscin in Homogenates of Rat Organs
Biophysics, 2019Abstract—The amounts of lipofuscin (age pigment) were compared in four organs of rats: the liver, the kidney, the heart muscle, and the brain, as well as in a suspension of ghosts of hepatic mitochondria. It was shown that liver lipofuscin, which absorbs UV light at 360 nm and fluoresces at 460 nm, is predominantly formed due to mitochondrial processes.
A. V. Chaplygina, N. L. Vekshin
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Lipofuscin and Macular Degeneration
Nutrition Reviews, 2003The accumulation of the autofluorescent pigment lipofuscin in the retina that occurs with aging has been explained as a side effect of the visual cycle. It occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the discs of the rod outer segments, and is followed by uptake into retinal pigment ...
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Catabolism of the Lipofuscin Cycloretinal by MsP1
Biochemistry, 2022Age-related macular degeneration (AMD) is a debilitating eye disease that tends to affect people over the age of 55. Lipofuscins are autofluorescent, toxic byproducts of the visual cycle thought to contribute toward the progression of the disease. Targeting the accumulation of lipofuscin through catabolism may serve as a method for the early treatment ...
Irum Perveen +6 more
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Potential reversibility of lipofuscin accumulation
Archives of Gerontology and Geriatrics, 2002It is well established that the lipofuscin content of many post-mitotic cell types increases progressively during normal senescence. This age-related accumulation of lipofuscin may occur either: (1) because lipofuscin, once formed, is never degraded or eliminated from cells; or (2) because, despite turnover of this pigment, the rate of lipofuscin ...
Martin Katz
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Action spectra for the photoconsumption of oxygen by human ocular lipofuscin and lipofuscin extracts
Archives of Biochemistry and Biophysics, 2002The action spectra for the photoconsumption of oxygen by lipofuscin isolated from human retinal pigment epithelium cells and liposomal suspensions containing extracts of lipofuscin are reported. The lipofuscin and lipofuscin extract action spectra are similar, demonstrating the phototoxic constituents of lipofuscin are present in the lipofuscin solvent
Anna, Pawlak +5 more
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Lipofuscin in human tongue muscle
Journal of Oral Pathology & Medicine, 1979Abstract In a study of 107 tongue specimens lipofuscin granules were found to be present in the Muscle fibers of 93 % of the cases. The pigment was not found in young individuals under the age of 18 years. The pigmented granules, which were stored in clusters of different sizes at the nuclear poles, were PAS‐positive, stained black or brown with the ...
D, Dayan, R, David, A, Buchner
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The effect of lipofuscin on cellular function
Mechanisms of Ageing and Development, 1983The neurons of the supraoptic nucleus of male C57BL/Icrfat mice at 6 or 28 months of age were examined from normally hydrated, osmotically loaded and osmotically loaded-rehydrated animals. Using quantitative morphological techniques, a reduction in the concentration of lipofuscin in the neurons was observed in osmotically loaded mice at both ages, and ...
Davies, I, Fotheringham, A, Roberts, C
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Nutrition Reviews, 2009
Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
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Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
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1987
Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
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Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
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Lipofuscin in Amyotrophic Lateral Sclerosis
Archives of Neurology, 1984Lipofuscin has been reported to accumulate in abnormal amounts in motor neurons of patients with amyotrophic lateral sclerosis (ALS). Microdensitometry was used to quantitate such lipid masses in spinal motor neurons in normal subjects compared with spinal motor neurons in ALS cases.
G B, McHolm, M J, Aguilar, F H, Norris
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