Results 151 to 160 of about 18,102 (192)
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Quantification of age pigments (lipofuscin)
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19881. Three methods have hitherto been applied for age pigment quantification: (a) numerically from micrographs; (b) fluorimetrically from histological sections; (c) spectrofluorimetrically from dissolved age pigments. 2. The spectrofluorimetric method is at present the most commonly used technique for quantification of age pigments. 3.
C, Hammer, E, Braum
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1987
Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
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Vitamin A, vitamin E, and phospholipids containing polyunsaturated fatty acids play important roles in both the structure and function of the retina, especially with regard to the photoreceptor cells (Robison et al., 1982). Deficiencies in dietary vitamin A, in forms which can be utilized as retinol, lead to night blindness, loss of photoreceptor outer
W. Gerald Robison, Martin L. Katz
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LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS
Gerontology, 2009Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipoftiscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell numbers significantly. Artificial lipofuscin-like material can be prepared by UV-crosslinking of mitochondria]
T, von Zglinicki +3 more
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Lipofuscin in human tongue muscle
Journal of Oral Pathology & Medicine, 1979Abstract In a study of 107 tongue specimens lipofuscin granules were found to be present in the Muscle fibers of 93 % of the cases. The pigment was not found in young individuals under the age of 18 years. The pigmented granules, which were stored in clusters of different sizes at the nuclear poles, were PAS‐positive, stained black or brown with the ...
D, Dayan, R, David, A, Buchner
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Lipofuscin in Amyotrophic Lateral Sclerosis
Archives of Neurology, 1984Lipofuscin has been reported to accumulate in abnormal amounts in motor neurons of patients with amyotrophic lateral sclerosis (ALS). Microdensitometry was used to quantitate such lipid masses in spinal motor neurons in normal subjects compared with spinal motor neurons in ALS cases.
G B, McHolm, M J, Aguilar, F H, Norris
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The effect of lipofuscin on cellular function
Mechanisms of Ageing and Development, 1983The neurons of the supraoptic nucleus of male C57BL/Icrfat mice at 6 or 28 months of age were examined from normally hydrated, osmotically loaded and osmotically loaded-rehydrated animals. Using quantitative morphological techniques, a reduction in the concentration of lipofuscin in the neurons was observed in osmotically loaded mice at both ages, and ...
Davies, I, Fotheringham, A, Roberts, C
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Hepatocellular Lipofuscin in Pre‐Eclampsia
Asia-Oceania Journal of Obstetrics and Gynaecology, 1989AbstractThirty liver specimens from 30 pre‐eclamptic women with and without liver dysfunction were examined for the amount of lipofuscin pigment deposited. The amount of hepatic lipofuscin correlated positively with plasma urate concentrations. This finding may indicate an involvement of oxygen‐free radicals and xanthine oxidase in the pathophysiology ...
H, Minakami +4 more
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The origin of lipofuscin age pigments
Experimental Gerontology, 1968Abstract The accumulation of lipofuscin pigments in post-mitotic cells has become well-established as an age-correlated process, and extensive studies have served to characterize these pigments. Numerous investigators have propounded a genesis for such pigments as a discrete process from varying cell organelles.
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Potential reversibility of lipofuscin accumulation
Archives of Gerontology and Geriatrics, 2002It is well established that the lipofuscin content of many post-mitotic cell types increases progressively during normal senescence. This age-related accumulation of lipofuscin may occur either: (1) because lipofuscin, once formed, is never degraded or eliminated from cells; or (2) because, despite turnover of this pigment, the rate of lipofuscin ...
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Can Lipofuscin Accumulation Be Prevented?
Rejuvenation Research, 2008During normal autophagic degradation of mitochondria and iron-containing proteins in lysosomes, iron is released intralysosomally where it may react with hydrogen peroxide forming hydroxyl radicals (Fenton reaction). Depending on their rate of formation, these highly reactive radicals can cross-link intralysosomal material, leading to lipofuscin ...
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