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Quantification of age pigments (lipofuscin)
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19881. Three methods have hitherto been applied for age pigment quantification: (a) numerically from micrographs; (b) fluorimetrically from histological sections; (c) spectrofluorimetrically from dissolved age pigments. 2. The spectrofluorimetric method is at present the most commonly used technique for quantification of age pigments. 3.
C, Hammer, E, Braum
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LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS
Gerontology, 2009Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipoftiscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell numbers significantly. Artificial lipofuscin-like material can be prepared by UV-crosslinking of mitochondria]
T, von Zglinicki +3 more
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Hepatocellular Lipofuscin in Pre‐Eclampsia
Asia-Oceania Journal of Obstetrics and Gynaecology, 1989AbstractThirty liver specimens from 30 pre‐eclamptic women with and without liver dysfunction were examined for the amount of lipofuscin pigment deposited. The amount of hepatic lipofuscin correlated positively with plasma urate concentrations. This finding may indicate an involvement of oxygen‐free radicals and xanthine oxidase in the pathophysiology ...
H, Minakami +4 more
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The origin of lipofuscin age pigments
Experimental Gerontology, 1968Abstract The accumulation of lipofuscin pigments in post-mitotic cells has become well-established as an age-correlated process, and extensive studies have served to characterize these pigments. Numerous investigators have propounded a genesis for such pigments as a discrete process from varying cell organelles.
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The effect of aluminium on neuronal lipofuscin
Mechanisms of Ageing and Development, 1983Adult white rats were injected over a period of 33 days with aluminum hydrochloride, while a control group, matched for age, sex and weight, received water injections only. At the end of that period, it was found that the group of rats which had received aluminum had lost weight.
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Can Lipofuscin Accumulation Be Prevented?
Rejuvenation Research, 2008During normal autophagic degradation of mitochondria and iron-containing proteins in lysosomes, iron is released intralysosomally where it may react with hydrogen peroxide forming hydroxyl radicals (Fenton reaction). Depending on their rate of formation, these highly reactive radicals can cross-link intralysosomal material, leading to lipofuscin ...
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Reducing lipofuscin accumulation and cardiomyocytic senescence of aging heart by enhancing autophagy
Experimental Cell Research, 2021Yu-Zhen Tan +2 more
exaly
Tsitologiia, 1978
Brain tissues of rats, mice and humans taken during autopsy were incubated in the medium containing 3,3'-diaminobenzidine (DAB), permitting to recognize mitochondrial cytochromes. The product of DAB oxidation was located in mitochondria and lypofuscin granules of the studied objects. Besides, the reaction product was found in the rat's brain structures
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Brain tissues of rats, mice and humans taken during autopsy were incubated in the medium containing 3,3'-diaminobenzidine (DAB), permitting to recognize mitochondrial cytochromes. The product of DAB oxidation was located in mitochondria and lypofuscin granules of the studied objects. Besides, the reaction product was found in the rat's brain structures
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Composition for inhibiting lipofuscin accumulation or removing lipofuscin
2022KIM EUNMI +3 more
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Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization
Proceedings of the National Academy of Sciences of the United States of America, 2021Kalpita Banerjee +2 more
exaly