Results 141 to 150 of about 17,764 (195)
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International Journal of Biochemistry and Cell Biology, 2004
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity.
Ulf T Brunk, Alexei Terman
exaly +4 more sources
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate that inversely correlates with longevity.
Ulf T Brunk, Alexei Terman
exaly +4 more sources
Annals of the New York Academy of Sciences, 2007
Abstract: One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins ...
, Tilman Grune
exaly +3 more sources
Abstract: One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins ...
, Tilman Grune
exaly +3 more sources
Lipofuscin and lipofuscin-like substances
Chemistry and Physics of Lipids, 1987Lipofuscin is defined as being a yellowish brown, lipid-rich, heterogeneous, cytoplasmic granular pigment emitting an intense yellow autofluorescence when excited with ultraviolet light, which accumulates in various tissues of animals during their aging.
K Aibara, Kageaki Aibara
exaly +3 more sources
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1983
An overview of the melanins and lipofuscin is presented, taking an integrating account of their morphological relationships and chemical characteristics wherever possible. This has required inclusion of the ommochromes, the schlerotizing process, and consideration of related neurotransmitters. A number of questions are raised and commented upon.
M H, Hack, F M, Helmy
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An overview of the melanins and lipofuscin is presented, taking an integrating account of their morphological relationships and chemical characteristics wherever possible. This has required inclusion of the ommochromes, the schlerotizing process, and consideration of related neurotransmitters. A number of questions are raised and commented upon.
M H, Hack, F M, Helmy
openaire +2 more sources
Understanding RPE Lipofuscin [PDF]
Investigative Opthalmology & Visual Science, 2013 Janet Sparrow, , Dean Bok
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2015
Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration.
Rosalie K, Crouch +4 more
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Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration.
Rosalie K, Crouch +4 more
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The photoreactivity of ocular lipofuscin
Photochemical & Photobiological Sciences, 2004Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity.
Boulton, M +3 more
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Lipofuscin and transsynaptic degeneration
Virchows Archiv A Pathological Anatomy and Histology, 1978The periodic acid Schiff reaction was applied to neurones in the Lateral Geniculate Body (L.G.B.) of a series of normal and blind patients over a wide age range. The quantity of the reaction product was determined as a measure of lipofuscin which was found to increase linearly with age in the L.G.B. neurones.
C L, Scholtz, A, Brown
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Lipofuscin: formation, effects and role of macroautophagy
Redox Biology, 2013 Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin.
Annika Hohn, Tilman Grune
exaly +4 more sources
Lipofuscin in Cardiac Hypertrophy
Beiträge zur Pathologie, 1972Summary Quantitative investigations on the lipofuscin content in human hearts from various weight classes should allow us to conclude whether or not a correlation exists between pigment content and the degree of cardiac hypertrophy. The investigations were performed on 7 μ thick tissue sections from 12 autopsied hearts, and included microscopic ...
W, Sandritter +3 more
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