Results 161 to 170 of about 89,481 (251)

Context-Dependent Modulation of Lipolytic Activity by <i>Ginkgo biloba</i> Extract: Evidence from Murine and Human Adipose Models. [PDF]

Pharmaceuticals (Basel)
Cavalcante II, de Almeida CDG, Thomaz FM, Simão JJ, Belaunde LHZ, Oyama LM, Ribeiro EB, Alonso-Vale MIC, Telles MM.   +8 more
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Heterogeneity of Cardiomyocyte Lipid Droplets and Their Pathophysiological Implications in Cardiovascular Diseases. [PDF]

Cells
Lei X, Zhang W.
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

Extracellular vesicles in cancer-associated cachexia: molecular mechanisms and therapeutic perspectives. [PDF]

Front Cell Dev Biol
Xie A, Wu S, Zeng W, Zhang M, Wang J, Shi L, Wu N, Hu B, Ye J, Zou Z, Li L, Zhou L.   +11 more
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Cold Stress-Induced Adipose Tissue Remodeling in <i>Min pigs</i>: Involvement of the <i>ADRB3</i>-ERK Axis, Autophagy, and Inflammatory Pathways. [PDF]

Biomolecules
Yang S, Chen H, Zhang D, He X, Ma H, Guo Z, Wang L, Fu B, Wang W, Liu D.   +9 more
europepmc   +1 more source

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Hepatic GHR deletion alters bile acid composition and links reduced FXR signaling to hepatic steatosis. [PDF]

Front Endocrinol (Lausanne)
Ran L, Li R, Wang Y, Liu X, Wu Y, Yu Z.
europepmc   +1 more source