Results 191 to 200 of about 24,712 (234)
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Solid-Phase Synthesis of Octapeptin Lipopeptides
2019Octapeptins are naturally derived cyclic lipopeptide antibiotics with activity against a range of Gram-negative pathogens, including highly resistant strains. Octapeptin C4, an exemplar of the class, was synthesized using a combination of Fmoc solid-phase peptide synthesis (SPPS) and solution-phase cyclization.
Hansford, Karl A. +3 more
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Bioresource Technology, 2013
The removal of Cu(2+), Zn(2+), Cd(2+), Pb(2+) and Hg(2+) from aqueous solution by lipopeptides produced from solid-state fermentation (LPSSF) and LPSSF modified Na-montmorillonite clays (LPSSF/Na-MMT) was investigated. The results showed that the LPSSF had certain adsorption capability for the metal ions and the modification of Na-MMT with LPSSF at a ...
Zhen, Zhu +6 more
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The removal of Cu(2+), Zn(2+), Cd(2+), Pb(2+) and Hg(2+) from aqueous solution by lipopeptides produced from solid-state fermentation (LPSSF) and LPSSF modified Na-montmorillonite clays (LPSSF/Na-MMT) was investigated. The results showed that the LPSSF had certain adsorption capability for the metal ions and the modification of Na-MMT with LPSSF at a ...
Zhen, Zhu +6 more
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Therapeutic Update on Glycopeptide and Lipopeptide Antibiotics
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1988Glycopeptide antibiotics in the form of vancomycin have been available for almost 30 years. In the past, vancomycin usually was reserved as an alternative agent to treat staphylococcal and streptococcal infection in patients with a penicillin allergy or hemodialysis shunt infection. With the increasing frequency of both methicillin‐
J C, Rotschafer +2 more
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Novel dendrimeric lipopeptides with antifungal activity
Bioorganic & Medicinal Chemistry Letters, 2012A series of new cationic lipopeptides containing branched, amphiphilic polar head derived from (Lys)Lys(Lys) dendron and C(8) or C(12) chain at C-end were designed, synthesized and characterized. Antimicrobial in vitro activity expressed as minimal inhibitory concentration (MIC) was evaluated against Gram-positive and Gram-negative bacteria and yeasts ...
Jolanta, Janiszewska +6 more
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The Cyclic Lipopeptide Antibiotics
2017The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the semi-synthetic lipoglycopeptides. These natural products and natural product derivatives most often originate from soil-inhabiting and/or plant-derived producing organisms.
Laurens H. J. Kleijn +1 more
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Biocompatible Lipopeptide-Based Antibacterial Hydrogel
Biomacromolecules, 2019A biocompatible hydrogel containing a hexapeptide as a key unit has been designed and fabricated. Our design construct comprises a β-sheet-rich short hexapeptide in the center with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C-terminals, respectively.
Anindyasundar Adak +3 more
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Daptomycin: A novel cyclic lipopeptide antimicrobial
American Journal of Health-System Pharmacy, 2005The development, activity, pharmacokinetics, pharmacodynamics, clinical efficacy, adverse effects, and dosage and administration of daptomycin are reviewed.Daptomycin, a novel cyclic lipopeptide antimicrobial, is bactericidal against a range of gram-positive bacteria, including many multiple-drug-resistant isolates. It has only minimal activity against
Christopher A, Schriever +3 more
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Biophysical studies of lipopeptide‐membrane interactions
Biopolymers, 1997There are a number of naturally occurring motifs for lipidation of peptides and proteins. In cases in which this involves adding a single hydrocarbon chain to the peptide, it is either a fatty acid or an isoprenyl group. Lipopeptides will partition between membrane and aqueous phases.
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Glycopeptides, Lipopeptides, and Lipoglycopeptides
2011Due to increasing resistance in Gram-positive organisms, use of glycopeptides, lipopeptides, and lipoglycopeptides will steadily increase. These three classes of drugs are primarily renally eliminated; therefore, CYP 450 interactions are not of concern.
Mary A. Ullman, John C. Rotschafer
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