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Liposomes for the Delivery of Lipopeptide Vaccines

2021
Liposomes, which are artificial phospholipid vesicles with a bilayer membrane structure, have been developed and evaluated as a promising delivery system for vaccines. Here, we describe a procedure for the encapsulation of lipopeptide vaccines into liposomes. A liposomal formulation of lipid-core peptide was prepared via thin-film hydration followed by
Yang, Jieru   +3 more
openaire   +4 more sources

Lipopeptide preparation and analysis

2000
Lipophilic peptides and proteins present specific problems during preparation and analysis which require the use of modified methodology. This chapter discusses some of the methods that have been employed in the isolation and structural studies of the pulmonary surfactant-associated proteins B and C (SP-B and SP-C), other proteins with lipid-like ...
J, Johansson   +4 more
openaire   +2 more sources

Biosynthesis of isonitrile lipopeptides

Current Opinion in Chemical Biology
Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α ...
Kaimin Jia   +3 more
openaire   +2 more sources

Synthesis of Lipopeptides by CLipPA Chemistry

2021
Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim   +3 more
openaire   +2 more sources

Lipopeptide adjuvants in combination treatment

International Immunopharmacology, 2003
Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the ...
Bessler, Wolfgang G.   +3 more
openaire   +3 more sources

Synthetische Lipopeptide

2009
Lipoproteine mit der N-terminalen Struktur des Trispalmitoyl-Cysteins (Pam3Cys) finden sich in den Membranen einer Vielzahl von Bakterien. Strukturanaloge synthetische Lipopeptide sind zudem Gegenstand intensiver Forschungen bezüglich einer therapeutischen Anwendung als Adjuvantien.
openaire   +1 more source

Iturin: cyclic lipopeptide with multifunction biological potential

Critical Reviews in Food Science and Nutrition, 2022
Chunpeng Wan   +2 more
exaly  

A critical review on the environmental application of lipopeptide micelles

Bioresource Technology, 2021
Bing Chen, Baiyu Zhang, Kenneth Lee
exaly  

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