Results 181 to 190 of about 24,712 (234)

Characterization of Bacillus velezensis UTB96, Demonstrating Improved Lipopeptide Production Compared to the Strain B. velezensis FZB42 [PDF]

Microorganisms, 2022
Bacillus strains can produce various lipopeptides, known for their antifungal properties. This makes them attractive metabolites for applications in agriculture.
Rudolf Hausmann, Marius Henkel, Ralf Voegelé   +2 more
exaly   +3 more sources

Induction of Cytotoxic T-Lymphocytes and Antitumor Activity by a Liposomal Lipopeptide Vaccine [PDF]

Molecular Pharmaceutics, 2008
We have previously described a simple yet effective liposome-based therapeutic vaccine, DOTAP/E7, which contains only two molecules, the cationic lipid DOTAP and a peptide antigen derived from the E7 oncoprotein of human papillomavirus (HPV) type 16.
Huan Xu
exaly   +3 more sources

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Synthesis of Lipopeptides by CLipPA Chemistry

2021
Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol ...
Victor, Yim, Yann O, Hermant, Paul W R, Harris, Margaret A, Brimble   +3 more
openaire   +2 more sources

Lipopeptide preparation and analysis

2000
Lipophilic peptides and proteins present specific problems during preparation and analysis which require the use of modified methodology. This chapter discusses some of the methods that have been employed in the isolation and structural studies of the pulmonary surfactant-associated proteins B and C (SP-B and SP-C), other proteins with lipid-like ...
J, Johansson, M, Stark, M, Gustafsson, Y, Wang, S, Zaltash   +4 more
openaire   +2 more sources

Structure–Activity Relationships of Daptomycin Lipopeptides

Journal of Medicinal Chemistry, 2020
Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of drug-resistant Gram-positive infections. It is most commonly used clinically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus ...
John A. Karas, Glen P. Carter, Benjamin P. Howden, Adrianna M. Turner, Olivia K. A. Paulin, James D. Swarbrick, Mark. A. Baker, Jian Li, Tony Velkov   +8 more
openaire   +3 more sources

Biosynthesis of isonitrile lipopeptides

Current Opinion in Chemical Biology
Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α ...
Kaimin Jia, Helen Sun, Yiyan Zhou, Wenjun Zhang   +3 more
openaire   +2 more sources

Synthetic lipopeptides as novel adjuvants

Research in Immunology, 1992
Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens. Lipopeptides are non-toxic, non-pyrogenic and do not induce tissue damage when injected.
W G, Bessler, G, Jung
openaire   +2 more sources

Lipopeptide adjuvants in combination treatment

International Immunopharmacology, 2003
Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine (P(3)CSK(4)) markedly enhanced the ...
Bessler, Wolfgang G., Mittenbühler, Klaus, Esche, Ulrich vor dem, Huber, Maria   +3 more
openaire   +3 more sources

Enrichment and Purification of Lipopeptide Biosurfactants

2010
A great many methods are available for the concentration of biosurfactants from microbiological media. The strongest known biosurfactant, surfactin, serves as a model in many studies, so is used here to illustrate the diversity in approaches to product enrichment.
Simon C, Baker, Chien-Yen, Chen
openaire   +2 more sources

Synthetische Lipopeptide

2009
Lipoproteine mit der N-terminalen Struktur des Trispalmitoyl-Cysteins (Pam3Cys) finden sich in den Membranen einer Vielzahl von Bakterien. Strukturanaloge synthetische Lipopeptide sind zudem Gegenstand intensiver Forschungen bezüglich einer therapeutischen Anwendung als Adjuvantien.
openaire   +1 more source