Anticancer Activities of Surfactin and Potential Application of Nanotechnology Assisted Surfactin Delivery [PDF]
ثبت أن السطحي، وهو خافض حيوي دوري للببتيد الدهني تنتجه سلالات مختلفة من جنس العصوية، يحفز السمية الخلوية ضد العديد من أنواع السرطان، مثل استسقاء إرليخ وسرطان الثدي والقولون وسرطان الدم والورم الكبدي. يمكن للعلاج بالسطح أن يمنع تطور السرطان عن طريق تثبيط النمو، وتوقف دورة الخلية، والاستماتة، وتوقف النقائل. نظرًا للتأثير القوي للسطح على الخلايا السرطانية،
Kok Gan Chan +2 more
exaly +4 more sources
Differential Impact of Ergosterol on Yeast Membranes Exposed to Membrane-Targeting Antimicrobial Compounds. [PDF]
Biomimetic membranes (liposomes) were prepared from yeast phospholipids with variable concentrations of ergosterol and exposed to antimicrobial compounds. Dynamic and electrophoretic light scattering measured changes in size and ζ‐potential to study their interaction with the antimicrobial compounds.
Villacres JI, Shaikhet M, Avis TJ.
europepmc +2 more sources
An Economical Bioprocess for Lipopeptide Production From Bacillus subtilis. [PDF]
The lipopeptide (LP) production potential of Bacillus isolates was evaluated against phytopathogenic fungi, with B. subtilis 4‐Ka‐22 identified as the top‐performing strain. Optimization of the production medium—comprising molasses, soybean meal, CaCl2, and glycerol—resulted in a 13.4‐fold increase in cell growth and over 99% cost reduction compared to
Maral-Gül D, Günay Z, Mis B, Eltem R.
europepmc +2 more sources
ACR3 as a Key Regulator Antimicrobial Lipopeptide Synthesis and Efflux in Bacillus velezensis HN-1. [PDF]
Lipopeptides are natural antibiotics produced by Bacillus velezensis. Mutation of acr3 led to the complete loss of antimicrobial activity. Following the biological assays for validation, we found ACR3 protein may serve as a master switch of lipopeptides synthesis regulation, and control transmembrane transport of lipopeptides by the ABC pathway ...
Shen Y +10 more
europepmc +2 more sources
Antifungal Activity of Surfactin Against <i>Cytospora chrysosperma</i>. [PDF]
Cytospora chrysosperma is a common opportunistically parasitic fungus that mainly infects forest trees, severely restricting the development of the fruit and forest industry. Surfactin is a secondary metabolite produced by Bacillus species and exhibits antifungal activity; Although the core antifungal mechanism of surfactin against plant pathogens has ...
Wang X +6 more
europepmc +4 more sources
Isolation and characterization of a new variant of surfactin, the [Val7]surfactin [PDF]
Reinvestigation of surfactin, a previously studied peptidolipid surfactant from Bacillus subtilis, by fast‐atom‐bombardment mass spectrometry and 1H‐NMR spectroscopy, as well as by chemical methods, revealed the presence of a closely related second constituent. This new compound, [Val7]surfactin, differs from the known surfactin by the C‐terminal amino
Peypoux, M +5 more
openaire +3 more sources
Surfactin and surfactin-like production, purification, and application at marine environments
Surfactin, a biosurfactant with great activity on interfaces, have been reported as a great substitute to non-renewable sources, non-biologically synthesized surfactants. It is expected to see more studies at the next years evolving its application, including on marine environments, especially ones impacted with petroleum or other contaminants. In this
Leticia Dobler +5 more
openaire +1 more source
Enrichment and Isolation of Surfactin-degrading Bacteria
A total of 100 environmental samples were investigated for their ability to degrade 1 g/L surfactin as a substrate. Among them, two enrichment cultures, which exhibited microbial growth as well as surfactin degradation, were selected and further investigated.
Habe, Hiroshi +3 more
openaire +3 more sources
Surfactin-type lipopeptides are suspected of being implicated in the rare food poisonings caused by Bacillus species outside the Bacillus cereus cluster. In order to get information on surfactin levels in actual human foods, bacilli from three commercial samples of a Japanese traditional bean product, natto, were isolated in order to clarify their ...
Mari, Juola +3 more
openaire +2 more sources
Interactions of surfactin with membrane models
Surfactin, an acidic cyclic lipopeptide produced by strains of Bacillus subtilis, is a powerful biosurfactant possessing biological activities. Interactions of ionized surfactin (two negative charges) with lecithin vesicles have been monitored by changes in its CD spectra. These changes are more important in the presence of Ca2+ ions.
Maget-Dana, R., Ptak, M.
openaire +2 more sources

