Anticancer Activities of Surfactin and Potential Application of Nanotechnology Assisted Surfactin Delivery [PDF]
Frontiers in Pharmacology, 2017 Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma.
Learn-Han Lee, Bey Hing Goh
exaly +8 more sources
Antifungal Activity of Surfactin Against Cytospora chrysosperma [PDF]
BiomoleculesCytospora chrysosperma is a common opportunistically parasitic fungus that mainly infects forest trees, severely restricting the development of the fruit and forest industry.
Xinyue Wang +6 more
doaj +5 more sources
Molecular genetics of surfactin and its effects on different sub-populations of Bacillus subtilis
Biotechnology Reports (Amsterdam, Netherlands), 2021 Surfactin is a biosurfactant produced by Bacillus subtilis. The srfA operon, Sfp gene, and two quorum sensing systems are required for its production. The master regulator spo0A also plays an indispensable role in proper surfactin synthesis.
Bishajit Sarkar +2 more
exaly +3 more sources
Exploring the metabolic burden of surfactin biosynthesis and the metabolic costs of srfA operon expression in Bacillus subtilis [PDF]
Microbial Cell FactoriesThe biosynthesis of surfactin, a potent lipopeptide biosurfactant produced by Bacillus subtilis, imposes a significant metabolic burden on the host organism.
Elvio Henrique Benatto Perino +8 more
doaj +2 more sources
Exploiting the ability of Bacillus subtilis to synthetize surfactin under oxygen limitation [PDF]
Applied Microbiology and BiotechnologySurfactin production by Bacillus subtilis is typically performed under aerobic conditions, requiring high aeration and agitation, which leads to mechanical stress for the cells and therefore promotes excessive foaming.
Eric Hiller +5 more
doaj +2 more sources
An Economical Bioprocess for Lipopeptide Production From Bacillus subtilis. [PDF]
MicrobiologyopenThe lipopeptide (LP) production potential of Bacillus isolates was evaluated against phytopathogenic fungi, with B. subtilis 4‐Ka‐22 identified as the top‐performing strain. Optimization of the production medium—comprising molasses, soybean meal, CaCl2, and glycerol—resulted in a 13.4‐fold increase in cell growth and over 99% cost reduction compared to
Maral-Gül D, Günay Z, Mis B, Eltem R.
europepmc +2 more sources
Functional Implications of Marine Biosurfactants and Their Therapeutic Potential Against Alzheimer's Disease. [PDF]
Food Sci NutrMarine‐derived biosurfactants produced by microorganisms (including bacteria, fungi, and yeast) have amphiphilic properties that facilitate membrane interactions and transport across the blood–brain barrier (BBB). These biosurfactants exhibit neuroprotective activity by targeting mechanisms implicated in Alzheimer's disease, including reducing ...
Irfan Z +4 more
europepmc +2 more sources
Toward Sustainable Crop Production in a Changing Climate: Microbiomes, Pathogens, Biostimulants and Biocontrol Innovations. [PDF]
Microb BiotechnolOverview of the impacts of climate change on plant–microbe interactions and the plant microbiome, as well as emerging microbial biotechnological strategies for sustainable crop protection.ABSTRACTClimate change is recognised as one of the most pressing global challenges, with profound consequences for plant health, agricultural productivity, and food ...
Holmes A, Matilla MA.
europepmc +2 more sources
Bioprospecting Indoor Bacteria Producing Bioactive Metabolites. [PDF]
Environ Microbiol RepThe indoor environments served as easily accessible habitats for bacteria producing mitochondrial toxins and ionophores, effects exhibited by known antiparasitic drugs and effects useful in mitochondrial research. This study describes the bacterial species and genera producing toxic peptide antibiotics and identifies some of their biological targets in
Andersson MA +4 more
europepmc +2 more sources
Surfactin Inhibits Osteoclast Differentiation by Negatively Regulating the Elk1-AP-1-NFATc1 Axis [PDF]
BiomedicinesBackground/Objectives: Surfactin is a biosurfactant with various biological activities, including antibacterial and anti-inflammatory properties; however, its effects on bone metabolism remain poorly understood.
Kazuki Maruyama +9 more
doaj +2 more sources