Results 31 to 40 of about 16,928 (191)

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide

Viruses, 2020
The highly conserved extracellular domain of the transmembrane protein M2 (M2e) of the influenza A virus is a promising target for the development of broad-spectrum vaccines. However, M2e is a poor immunogen by itself and must be linked to an appropriate
Anna A. Zykova, Elena A. Blokhina, Roman Y. Kotlyarov, Liudmila A. Stepanova, Liudmila M. Tsybalova, Victor V. Kuprianov, Nikolai V. Ravin   +6 more
doaj   +1 more source

Bacillus lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation

Journal of Enzyme Inhibition and Medicinal Chemistry
Bacillus lipopeptides have been reported to display anti-obesity effects. In the present study, Lipopeptides from Bacillus velezensis FJAT-45028 that consisted of iturin, fengycin and surfactin were reported.
Meichun Chen, Deju Chen, Rongfeng Xiao, Xuefang Zheng, Bo Liu, Jieping Wang   +5 more
doaj   +1 more source

MICROBIAL SURFACTANTS. II. LIPOPEPTIDES [PDF]

Biotechnologia Acta, 2014
The classification and the chemical structure of the lipopeptides and their producers (bacteria of the genera Bacillus and Pseudomonas) are given.
T. P. Pirog, A. D. Konon, A. P. Sofilkanich   +2 more
doaj   +1 more source

Interfacial and emulsifying properties of lipopeptides from Bacillus subtilis [PDF]

, 1999
peer reviewedThe fundamental surface-active properties at the oil/water interface and emulsifying properties of surfactin, iturin A and fengycin, lipopeptides from Bacillus subtilis, were investigated.
M Deleu, Paquot, Michel, H Razafindralambo, Razafindralambo, Hary, Y Popineau, P Thonart, M Paquot, Deleu, Magali, P Jacques, Popineau, Y., Jacques, Philippe, Thonart, Philippe   +11 more
core   +1 more source

Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria [PDF]

, 2021
Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty acid side chain.
Fewer, David P., Aesoy, Reidun, Lars Herfindal, Heinila, Lassi, Hrouzek, Pavel, Lassi Heinilä, Galica, Tomas, David P. Fewer, Reidun Aesoy, Tomáš Galica, Sivonen, Kaarina, Jouni Jokela, Kaarina Sivonen, Pavel Hrouzek, Herfindal, Lars, Jokela, Jouni   +15 more
core   +1 more source

Characterization of Lipopeptide Biosurfactants Produced by Bacillus licheniformis MB01 from Marine Sediments

Frontiers in Microbiology, 2017
Antibiotic resistance has become one of the world’s most severe problems because of the overuse of antibiotics. Antibiotic-resistant bacteria are more difficult to kill and more expensive to treat. Researchers have been studied on antibiotic alternatives
Yulin Chen, Yulin Chen, Shiliang A. Liu, Haijin Mou, Yunxiao Ma, Meng Li, Xiaoke Hu   +6 more
doaj   +1 more source

Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry

, 2023
Lipopeptides are amphiphilic peptides in which an aliphatic chain is attached to either the C or N terminus of peptides. Their self-assembly — into micelles, vesicles, nanotubes, fibres or nanobelts — leads to applications in nanotechnology, catalysis or
Vicente-García, C., Cesar Vicente-Garcia, Colomer, Ignacio, Ignacio Colomer   +3 more
core   +1 more source

The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. [PDF]

PLoS ONE, 2010
Natural killer (NK) cells are lymphocyte effectors that are activated to control certain microbial infections and tumors. Many NK-activating and regulating receptors are involved in regulating NK cell function.
Masahiro Azuma, Ryoko Sawahata, Yuusuke Akao, Takashi Ebihara, Sayuri Yamazaki, Misako Matsumoto, Masahito Hashimoto, Koichi Fukase, Yukari Fujimoto, Tsukasa Seya   +9 more
doaj   +1 more source