Results 51 to 60 of about 12,566 (192)

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

New Linear Lipopeptides Produced by Pseudomonas cichorii SF1-54 Are Involved in Virulence, Swarming Motility, and Biofilm Formation

Molecular Plant-Microbe Interactions, 2013
Pseudomonas cichorii is the causal agent of lettuce midrib rot, characterized by a dark-brown to green-black discoloration of the midrib. Formation of necrotic lesions by several plant-pathogenic pseudomonads is associated with production of phytotoxic ...
Ellen Pauwelyn, Chien-Jui Huang, Marc Ongena, Valérie Leclère, Philippe Jacques, Peter Bleyaert, Herbert Budzikiewicz, Mathias Schäfer, Monica Höfte   +8 more
doaj   +1 more source

Surfactant Enhanced Bioremediation of Saline Diesel Contaminated Water by a Novel Bacterial Halophilic Consortium

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT The use of microorganisms is an evolving method for the degradation of hydrocarbon contaminants. In this aim, halophilic hydrocarbon degrading bacteria were isolated from oil contaminated soil in Tunisia. A lipopeptide biosurfactant produced by Bacillus subtilis SPB1 was tested to increase diesel biodegradation along with co‐inoculation with ...
Inès Mnif, Dhouha Ghribi
wiley   +1 more source

In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity

Molecules, 2017
Owing to their excellent antimicrobial activities with a relatively low cost of production, lipopeptides are being intensively investigated as potential alternatives to popular antimicrobials.
Malgorzata Anna Dawgul, Katarzyna Ewa Greber, Sylwia Bartoszewska, Wioletta Baranska-Rybak, Wieslaw Sawicki, Wojciech Kamysz   +5 more
doaj   +1 more source

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions

Pest Management Science, EarlyView.
The surfactin C secreted by JDB15 and the probable parasitism of JDL4 lead to the leakage of intracellular macromolecules and the degradation of hyphae, respectively. Combined application of the two strains effectively controls banana Fusarium wilt under controlled conditions.
Deng Chen, Minghao Ju, Hongyang Li, Junting Feng, Xueyong Zi, Xuqian Gong, Yida Che, Xiaoya Lei, Zihuan Geng, Hongsen Deng, Kang Zhao, Jianghui Xie, Xiao‐Lin Chen, Jun Peng   +13 more
wiley   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Biocontrol of tomato bacterial wilt by the new strain Bacillus velezensis FJAT-46737 and its lipopeptides

BMC Microbiology, 2020
Background There is an urgent need to discover biocontrol agents to control bacterial wilt. This study reports on a new lipopeptide-producing biocontrol strain FJAT-46737 and explores its lipopeptidic compounds, and this study investigates the ...
Meichun Chen, Jieping Wang, Bo Liu, Yujing Zhu, Rongfeng Xiao, Wenjing Yang, Cibin Ge, Zheng Chen   +7 more
doaj   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source